Mitiglinide calcium
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- CAS-Nr.
- 145525-41-3
- Englisch Name:
- Mitiglinide calcium
- Synonyma:
- S21403;S 21403;S-21403;Mitiglinide calcium;Mitiglinide Calcium RS;MITIGLINIDE KAD-1229;Mitiglinide Calcium Salt;MITIGLINIDE CALCIUM HYDRATE;Mitiglinide hemicalcium salt;Mitiglinide calcium anhydrous
- CBNumber:
- CB8854809
- Summenformel:
- (C19H24NO3)2.Ca
- Molgewicht:
- 668.88
- MOL-Datei:
- 145525-41-3.mol
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Mitiglinide calcium Eigenschaften
- Schmelzpunkt:
- 146-148°C
- Dichte
- 1.175
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO: ≥10mg/mL at warmed to 60°C
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D +5 to +9° (c=1, MeOH)
- CAS Datenbank
- 145525-41-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
36 |
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| WGK Germany |
3 |
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| HS Code |
2933.99.7500 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Mitiglinide calcium Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells
Mode of action
Mitiglinide is another non-sulfonylurea insulin secretagogue. Insulin secretion is physiologically stimulated by the binding of ATP to a cytosolic nucleotide binding site of the membrane bound ATP-sensitive K+ channel which leads to closure of the K+ channel. The inhibition of K+ permeability depolarizes the plasma membrane, subsequently the voltage-dependent Ca2+ channel opens to promote the Ca2+ influx which finally results in insulin secretion. The insulin secretagogues stimulate insulin secretion by closure of this ATP-sensitive K+ channel of pancreatic -cells. KATP-channel consists of two subunits, a functional ion channel pore and a regulatory protein. The binding of the secretagogues is suggested to occur to the separate regulator protein containing the binding sites for sulfonylureas (sulfonylurea receptor 1, SUR1) but also other compounds.
Mitiglinide calcium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mitiglinide calcium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 242)Lieferanten
145525-41-3()Verwandte Suche:
- calcium 2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate
- (as,3ar,7as)-octahydro-gamma-oxo-alpha-(phenylmethyl)-2h-isoindole-2-butanoic acid calcium salt dihydrate
- MITIGLINIDE CALCIUM HYDRATE
- MITIGLINIDECALCIUM(FORR&DONLY)
- Monocalcium bis[(2S)-2-benzyl-3-(cis-hexahydro isoindolin -2-carbonyl)propionate]dihydrate
- MITIGLINIDE KAD-1229
- Mitiglinide calcium
- Mitiglinide calcium anhydrous
- (αS,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid, calcium salt (2:1)
- [2(S)-cis]-octahydro-γ-oxo-α-(phenylmethyl)-2H-Isoindole-2-buta
- octahydro-γ-oxo-α-(phenylmethyl)-2H-Isoindole-2-butanoic acid, calcium salt, (αS,3aR,7aS)- (9CI)
- 2H-Isoindole-2-butanoicacid, octahydro-g-oxo-a-(phenylMethyl)-, calciuM salt (2:1), (aS,3aR,7aS)-
- CalciuM 2-benzyl-4-((3aR,7aS)-hexahydro-1H-isoindol-2(3H)-yl)-4-oxobutanoate
- S 21403
- S21403
- S-21403
- CalciuM (S)-2-benzyl-4-((3aR,7aS)-hexahydro-1H-isoindol-2(3H)-yl)-4-oxobutanoate
- (aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt
- [2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt
- Mitiglinide hemicalcium salt
- Mitiglinide calcium chloride dihydrate
- (alphaS,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt
- calcium 4-(1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-4-oxo-2-(phenylmethyl)butanoate
- (2S)-Mitiglinide-d5 Calcium Salt
- Mitiglinide Calcium RS
- Mitiglinide Calcium Salt
- (alphaS,3aR,7aS)-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt
- Mitiglinide calcium USP/EP/BP
- Mitiglinide Calcium (KAD-1229)
- TIANFU CHEM-- Mitiglinide calcium
- Calcium (S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoate
- 2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, calcium salt (2:1), (αS,3aR,7aS)-
- (alphaS,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt
- 145525-41-3
- 900-61-9
- 122322-18-7
- C19H24NO32Ca
- C38H52CaN2O8
- 2C19H24NO3Ca
- C38H48CaN2O6
- C38H48CaN2O62H2O
- C19H25NO32Ca2H2O
- C19H24NO312Ca
- C19H25CaNO3
- Inhibitors
- API
- White crystal posder
- Pharmaceutical material and intermeidates
