Droperidol
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- CAS-Nr.
- 548-73-2
- Bezeichnung:
- Droperidol
- Englisch Name:
- DROPERIDOL
- Synonyma:
- R 474;r4749;Dridol;Halkan;Inoval;R 4749;Inappin;Inapsin;Innovan;Innovar
- CBNumber:
- CB9145418
- Summenformel:
- C22H22FN3O2
- Molgewicht:
- 379.43
- MOL-Datei:
- 548-73-2.mol
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Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
36 |
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| RIDADR |
3249 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DE2100000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
2933995800 |
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| Giftige Stoffe Daten |
548-73-2(Hazardous Substances Data) |
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| Toxizität |
LD50 oral in rat: 750mg/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Droperidol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
D roperidol is a butyrophenone that has potent antidopaminergic (D2)
activity and mild α2-blocking actions. It produces sedation and anxiolysis and
is an effective antiemetic. A dverse effects include
vasodilatation and hypotension, and at higher doses, dystonic reactions can
occur. D roperidol was used for premedication and in neuroleptanaesthesia
until reports of death from long QT syndrome led to its withdrawal in 2001. It
has recently been reintroduced and licenced at lower doses for prevention of
postoperative nausea and vomiting. D roperidol has an onset of 3–10 min
after i.v. injection and duration of action of 6–12h. It undergoes hepatic
metabolism, but approximately 10% of the drug is excreted unchanged in the
urine.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
The neuroleptic droperidol possesses antipsychotic, sedative, and antishock action. It potentiates the action of drugs for narcosis. In psychiatric practice, droperidol is used for psychomotor excitement and hallucinations. The principal use of this drug lies in anesthesiology
for neuroleptanalgesia in combination with fentanyl. It is used in premedication as well as in
surgical operations and post-operational circumstances.
Definition
ChEBI: An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the
management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeo
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Allgemeine Beschreibung
Droperidol, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2, 3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone(Inapsine), may be used alone as a preanestheticneuroleptic or as an antiemetic. Because of its very shortactingand highly sedating properties, its most frequent useis in combination (Innovar) with the narcotic agent fentanyl(Sublimaze) preanesthetically.
Droperidol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Droperidol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 226)Lieferanten
548-73-2(Droperidol)Verwandte Suche:
- 1-{1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone
- 2-Benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-
- 2-benzimidazolinone,1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyri
- 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-
- 3-dihydro-4-pyridinyl)-
- component of Innovar
- component of Thalamonal
- Dehidrobenzperidol
- Dehydrobenzperidol
- DROPERIDOL,USP
- 1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
- Neurolidol
- NSC 169874
- R 474
- 3-(1-(3-(4-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-1H-benzimidazol-2-one
- 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl]-2,3-dihydro-1H-benzimidazol-2-one
- 3-[1-[4-(4-fluorophenyl)-4-keto-butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
- 3-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
- 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
- Droperidol,1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
- Droperidol (250 mg)
- 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]iMidazol-2(3H)-one
- Droperidol-d4
- Deidrobenzperidolo
- Dihidrobenzperidol
- Dridol
- Droleptan
- Halkan
- Inappin
- Inapsin
- Inapsine
- Innovan
- Innovar
- Innovar-Vet
- Inopsin
- Inoval
- Leptanal
- Leptofen
- McN-JR 4749
- mcn-jr4749
- mcn-jr-4749
- Properidol
- R 4749
- r4749
- Sintodril
- Sintosian
- Thalamanol
- Thalamonal
- Vetkalm
- DROPERIDOL
- 1-(1-[4-FLUOROBENZOYLPROPYL]-1,2,3,6-TETRAHYDRO-4-PYRIDYL)-2-BENZIMIDAZOLINONE
- 1-[1-(P-FLUOROBENZOYLPROPYL)-1,2,3,6-TETRAHYDRO-4-PYRIDYL]-2-BENZIMIDAZOLINONE
- 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazo
- 1-(1-(3-(p-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
- 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-2h-benzimidazol-2-on
- 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimi
- 1-(1-(4-(p-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
- 1-(1-(4-(p-fluorophenyl-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidaz
