COMBRETASTATIN A-4
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- CAS-Nr.
- 117048-59-6
- Englisch Name:
- COMBRETASTATIN A-4
- Synonyma:
- CA4;CS-A4;CS-284;CRC 87-09;NSC 817373;NSC-817373;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4
- CBNumber:
- CB9496826
- Summenformel:
- C18H20O5
- Molgewicht:
- 316.35
- MOL-Datei:
- 117048-59-6.mol
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COMBRETASTATIN A-4 Eigenschaften
- Schmelzpunkt:
- 84.5-85.5°C
- Siedepunkt:
- 490.3±45.0 °C(Predicted)
- Dichte
- 1.184±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 9.65±0.10(Predicted)
- Farbe
- off-white
- Merck
- 14,2494
COMBRETASTATIN A-4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-
1 (pancreatic carcinoma), and MCF-
7 (breast cancer) with IC
50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC
50 value of 2.2 μM.
Chemische Eigenschaften
Crystalline Powder
Verwenden
Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
Allgemeine Beschreibung
Combretastatin A4 belong to the class of colchicinoids compounds.
Biologische Aktivität
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).
Anticancer Research
It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).
COMBRETASTATIN A-4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
COMBRETASTATIN A-4 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 284)Lieferanten
117048-59-6()Verwandte Suche:
- (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
- Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
- (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%
- 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- 3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol
- 5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol
- Combretastatin A4
- (Z)-CombretastatinA4
- combretastatin A-4 (CA-4)
- 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- Combrestatin A4
- (Z)-2-Methoxy-5-[2-(3,4,5-triMethoxyphenyl)ethenyl]phenol, 3,4,5-TriMethoxy-3'-hydroxy-4'-Methoxy-(Z)-stilbene
- CS-A4
- CoMbretastatin A
- CA-4, Combretastatin A-4
- 1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene
- CA4
- (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol
- 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
- (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol
- Combretastatin A4 117048-59-6
- Combretastatin A-4 - CAS 117048-59-6 - Calbiochem
- CS-284
- CRC 87-09
- 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z
- Combretastatin A4 (CRC 87-09)
- Combretastatin A4 >
- Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
- Recombinant Human Carbonic Anhydrase IV/CA4 Protein, His Tag
- 3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
- Combretastatin TXB-4
- NSC 817373
- NSC-817373
- 117048-59-6
- 17048-59-6
- Inhibitors
- Combretastatin
- API
- Anti-cancer & immunity
