Ginsenoside Rg3
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- CAS-Nr.
- 14197-60-5
- Englisch Name:
- Ginsenoside Rg3
- Synonyma:
- Rg3;CS-1328;gensenoside RG3;GINSENOSIDE RG3;opyransoyl)oxy)-;(20S)-PROPANAXADIOL;20S-Ginseniside Rg3;GINSENOSIDE Rg3(SH);Ginsenosides rg3(s);Ginsenoside Rg3 (S-)
- CBNumber:
- CB9713141
- Summenformel:
- C42H72O13
- Molgewicht:
- 785.03
- MOL-Datei:
- 14197-60-5.mol
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Ginsenoside Rg3 Eigenschaften
- Schmelzpunkt:
- 315-318°C
- Siedepunkt:
- 885.0±65.0 °C(Predicted)
- Dichte
- 1.30
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥5mg/mL
- pka
- 12.85±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D +10 to +20°, c = 1 in methanol
- InChIKey
- RWXIFXNRCLMQCD-JBVRGBGGSA-N
- CAS Datenbank
- 14197-60-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
LY9537300 |
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| HS Code |
29389090 |
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| Toxizität |
mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Ginsenoside Rg3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus
Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg
3 is a panaxadiol found in white and red
P. ginseng. This ginsenoside has diverse
in vitro and
in vivo effects, including anti-
cancer, neuroprotective, anti-
hypertensive, and anti-
inflammatory actions. Ginsenoside Rg
3 induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.
Verwenden
Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.
Biochem/physiol Actions
Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.
Ginsenoside Rg3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ginsenoside Rg3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 274)Lieferanten
14197-60-5()Verwandte Suche:
- beta-d-glucopyranoside,(3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl2-o-b
- dammar-24-ene-12-beta,20-diol,3-beta-((2-o-beta-d-glucopyranosyl-beta-d-gluc
- eta-d-glucopyranosyl-
- gensenoside RG3
- (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
- Rg3
- GINSENOSIDE RG3
- opyransoyl)oxy)-
- 20(s)-ginsenoside-rg3
- (20S)-PROPANAXADIOL
- Dammar-24-ene-12β,20-diol, 3β-[(2-O-β-D-
- glucopyranosyl-β-D-glucopyranosyl)oxy]-
- Ginsenoside 20(s)-Rg3
- (20S)-3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]dammarane-24-ene-12β,20-diol
- 12β,20-Dihydroxy-5α-dammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
- 20S-Ginseniside Rg3
- Ginsenoside Rg3 (S-)
- (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside
- GINSENOSIDE RG3(S-FORM)(P)
- GINSENOSIDE Rg3(SH)
- Ginsenoside Rg3 ,98%
- Monomer Ginsenoside Rg3
- (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-DIHYDROXY-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-HYDROXY-17-[(2S)-2-HYDROXY-6-METHYLHEPT-5-EN-2-YL]-4,4,8,10,14-PENTAMETHYL-2,3,5,6,7,9,11,12,13,15,16,17-DODECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-YL]OXY]-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL
- Ginsenoside Rg3, 98%, from Panax ginseng C. A. Mey.
- (11019-45-7) ginsenoside rg3
- Ginsenoside Rg3, ≥98%(HPLC)
- 2-[[4,5-dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)-3-oxany
- CS-1328
- Ginsenoside RG3 Natural Plant Extracts HPLC 15% 50% 98% 14197-60-5
- Ginsenoside Rg3 (S-Form)
- β-D-Glucopyranoside, (3β,12β)-12,20-dihydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
- (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
- Ginsenosides rg3(s)
- Ginsenoside S type Rg3
- 14197-60-5
- C42H72O11
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Ginsenoside series
- Saponins
- The group of Ginsenosides
