ChemicalBook >> CAS DataBase List >>Nintedanib Esylate

Nintedanib Esylate

Nintedanib Esylate structure

CAS No.: 656247-18-6

Chemical Name:: Nintedanib Esylate

Synonyms: Nintedanib esylate;Nintedanib ethanesulfonate;Nintedani;NSC 116056;BIBF-1120 esylate;BIBF 1120 esylate;Nintedanib (Ofev);BIBF 1120 BIBF-1120;Trinidad Neeb esylate;Intedanib ethanesulfonate

CBNumber:: CB00123189

Molecular Formula:: C33H39N5O7S

Molecular Weight:: 649.76

MDL Number:: MFCD26142360

MOL File:: 656247-18-6.mol

MSDS File:: SDS

Last updated:2024-04-02 13:34:07

Request For Quotation

Nintedanib Esylate Properties

Melting point	>233°C (dec.)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
form	Yellow solid.
color	Light Yellow to Yellow
FDA UNII	42F62RTZ4G

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Nintedanib Esylate price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	N478290	NintedanibEsylate	656247-18-6	5mg	$65	2021-12-16	Buy
ChemScene	CS-3475	Nintedanibesylate 99.93%	656247-18-6	10mg	$66	2021-12-16	Buy
AK Scientific	9942AL	Nintedanibesylate	656247-18-6	25mg	$67.2	2021-12-16	Buy
ChemScene	CS-3475	Nintedanibesylate 99.93%	656247-18-6	50mg	$96	2021-12-16	Buy
Biosynth Carbosynth	FD71497	Nintedanib ethanesulfonate	656247-18-6	50mg	$100	2021-12-16	Buy

Product number	Packaging	Price	Buy
N478290	5mg	$65	Buy
CS-3475	10mg	$66	Buy
9942AL	25mg	$67.2	Buy
CS-3475	50mg	$96	Buy
FD71497	50mg	$100	Buy

Nintedanib Esylate Chemical Properties,Uses,Production

Description

Nintedanib esylate is an organosulfonate salt obtained by combining nintedanib with one molar equivalent of ethanesulfonic acid. A kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an angiogenesis inhibitor, an antineoplastic agent, a fibroblast growth factor receptor antagonist, a tyrosine kinase inhibitor, and a vascular endothelial growth factor receptor antagonist. Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

Mechanism of action

Nintedanib Esylate is the salt form of Nintedanib. Nintedanib is a small molecule, competitive, triple angiokinase inhibitor that targets multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Many of these RTKs are implicated in lung fibrosis and tumor angiogenesis, so nintedanib is used to treat proliferative diseases such as idiopathic pulmonary fibrosis, non-small cell lung cancer, and systemic sclerosis-associated interstitial lung disease. The specific RTKs that nintedanib inhibits are platelet-derived growth factor (PDGFR) α and β, fibroblast growth factor receptor (FGFR) 1-3, vascular endothelial growth factor receptor (VEGFR) 1-3, and Fns-Like tyrosine kinase-3 (FLT3). Nintedanib binds to the ATP-binding pocket of these receptors and inhibits their activity, thereby blocking signaling cascades that result in the proliferation and migration of lung fibroblasts. Nintedanib also inhibits kinase signaling pathways in various cells within tumor tissues, including endothelial cells, pericytes, smooth muscle cells, and cells contributing to angiogenesis, culminating in an inhibition of cell proliferation and apoptosis of affected tumor cells.

Nintedanib Esylate Preparation Products And Raw materials

Raw materials

Ethanesulfonic acid Nintedanib Methyl 2-oxoindole-6-carboxylate 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester Methyl 1-acetyl-2-oxoindoline-6-carboxylate

2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE (3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester

1of2

Preparation Products

Nintedanib Esylate Suppliers

Global( 305)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6004	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15962	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Shanghai Bojing Chemical Co.,Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Lianyungang happen teng technology co., LTD	58

View Lastest Price from Nintedanib Esylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-09	Nintedanib Esylate 656247-18-6	US $0.00-0.00 / kg	1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd
2021-07-02	Nintedanib esylate 656247-18-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	Nintedanib Esylate 656247-18-6	US $1.00 / KG	1KG	98%	500kg	Career Henan Chemical Co

Nintedanib Esylate
656247-18-6
US $0.00-0.00 / kg
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Nintedanib esylate
656247-18-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Nintedanib Esylate
656247-18-6
US $1.00 / KG
98%
Career Henan Chemical Co

Nintedanib esylate Spectrum

Nintedanib Ethanesulfonate Salt(656247-18-6)¹HNMR

656247-18-6(Nintedanib Esylate)Related Search:

Nintedanib Methyl 2-oxoindole-6-carboxylate (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester BIBF-1120 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE

2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Ruxolitinib phosphate

Alectinib Hydrochloride PLX4032 Olaparib Crizotinib Afatinib (BIBW 2992)

PLERIXAFOR Propylparaben Methylparaben Nintedanib Esylate

1of4

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester ethanesulfonate BIBF 1120 esylate BIBF-1120 esylate BIBF1120/nintedanib ethanesulfonate salt Trinidad Neeb esylate Intedanib ethanesulfonate Nintedanib ethanesulfonate salt Trinidad Neeb ethanesulfonate Nintedanib(ethanesulfonic acid) BIBF1120 ethanesulfonate salt (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene 1H-Indole-6-carboxylic acid,2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]-phenylmethylene]-2-oxo-, methylester, (3Z)-, ethanesulfonate (1:1) 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1) Nintedanib (Ofev) (Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate BIBF 1120 BIBF-1120 BIBF1120; BIBF 1120 BIBF-1120; NINTEDANIB ESYLATE. NINTEDANIB ETHANESULFONATE SALT; INTEDANIB; BRAND NAME OFEV. VARGATEF. Brand name OFEV. Vargatef. Nintedanib esylate. Nintedanib ethanesulfonate salt Nintedanib Ethanesulfonate (Intedanib Ethanesulfonate) Nintedani NSC 116056 Nintedanib ethanesulfonate Nintedanib esylate 6-Benzofuranpropanenitrile,β-oxo- methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate Buprenorphine Impurity 24 656247-18-6 1217052-38-5 C31H33N5O4C2H6O3S C33H39N5O7S API