ChemicalBook >> CAS DataBase List >>4-Biphenylacetic acid

4-Biphenylacetic acid

CAS No.
5728-52-9
Chemical Name:
4-Biphenylacetic acid
Synonyms
FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
CBNumber:
CB0186272
Molecular Formula:
C14H12O2
Molecular Weight:
212.24
MDL Number:
MFCD00004351
MOL File:
5728-52-9.mol
MSDS File:
SDS
Last updated:2023-10-10 13:24:25

4-Biphenylacetic acid Properties

Melting point 159-160 °C (lit.)
Boiling point 312.08°C (rough estimate)
Density 1.1035 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble50mg/mL, clear, colorless to yellow
pka 4.29±0.10(Predicted)
form Powder
color Beige
Water Solubility 39.27mg/L(25 ºC)
Merck 14,3316
BRN 1211592
InChIKey QRZAKQDHEVVFRX-UHFFFAOYSA-N
CAS DataBase Reference 5728-52-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 94WNJ5U8L7
ATC code M02AA08

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H331-H315-H319-H335
Precautionary statements  P261-P264-P301+P310-P302+P352-P304+P340+P311-P305+P351+P338
Hazard Codes  T,Xn
Risk Statements  23/25-36/37/38-25-36/37/38/63-20/21/22
Safety Statements  26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DU8229050
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29163900
Toxicity LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)
NFPA 704
0
3 0

4-Biphenylacetic acid price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196487 4-Biphenylacetic acid 98% 5728-52-9 5g $60.2 2024-03-01 Buy
Sigma-Aldrich 196487 4-Biphenylacetic acid 98% 5728-52-9 25g $120 2023-01-07 Buy
TCI Chemical B1278 4-Biphenylacetic Acid >98.0%(HPLC)(T) 5728-52-9 25g $41 2024-03-01 Buy
TCI Chemical B1278 4-Biphenylacetic Acid >98.0%(HPLC)(T) 5728-52-9 250g $232 2024-03-01 Buy
Alfa Aesar A11749 4-Biphenylacetic acid, 98% 5728-52-9 50g $151 2023-06-20 Buy
Product number Packaging Price Buy
196487 5g $60.2 Buy
196487 25g $120 Buy
B1278 25g $41 Buy
B1278 250g $232 Buy
A11749 50g $151 Buy

4-Biphenylacetic acid Chemical Properties,Uses,Production

Description

Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.

Chemical Properties

Off-white powder

Originator

Lederle (USA)

Uses

Anti-inflammatory, analgesic drug.

Uses

4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.

Definition

ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.

brand name

Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).

General Description

4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.

Safety Profile

Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.

98-80-6
1878-68-8
5728-52-9
Synthesis of 4-Biphenylacetic acid from Phenylboronic acid and 4-Bromophenylacetic acid
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View Lastest Price from 4-Biphenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Biphenylacetic acid pictures 2024-01-02 4-Biphenylacetic acid
5728-52-9
US $50.00-500.00 / KG 1KG 0.99 20 tons HangYu Chemical Co.,Ltd
4-Biphenylacetic acid pictures 2023-09-08 4-Biphenylacetic acid
5728-52-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
biphenyl-4-ylacetic acid pictures 2023-09-04 biphenyl-4-ylacetic acid
5728-52-9
US $100.00 / kg 1kg 99% 20 tons Hebei Yanxi Chemical Co., Ltd.
4-BIPHENYLACETICABID Biphenyl-4-acetic acid 97% 4-Biphenylacetic acid/Felbinac 4 -BIPHENYLACETIC ACID 99% BP GRADE 4-BIPHENYL ACETIC ACID 98.5% 4-BIPHENYLACETIC ACID(METHOXYMETHYL)-1,1''-BIPHENYL 4-Biphenylacetic acid ,99% L-141 LJC-10141 LY-61017 4-Biphenylacetic aci 4-BIPHENYLYLACETIC ACID P-BIPHENYLYLACETIC ACID (Biphenyl-4-yl)acetic acid 97% 4-Biphenylacetic acid, 98% 10GR NSC 16284 Seltouch TraxaM 4-BIPHENYLYLACETIC ACID FOR SYNTHESIS Biphenyl acetic acid(Felbinac) Biphenyl-4-yl-acetic acid CI 83544 4-PHENYLPHENYLACETIC ACID 4-CARBOXYMETHYLBIPHENYL 4-BIPHENYLACETIC ACID 4-Diphenylacetic Acid P-BIPHENYLACETIC ACID RARECHEM AL BO 0343 Felbinac(4-BiphenylaceticAcid) 4-Biphenylaceticacid,98+% biphenyl acetic acide 4-biphenyl acetic acide 4-bisphenylacetic acid ( Felbinac) Flurbiprofen-d3 (2-Fluoro-a-trideuteromethyl-[1,1&rsquo Felbinac CRS 4-Biphenylacetic Acid > 4-Biphenylessigsaeure 2-([1,1'-biphenyl]-4-yl)acetic acid BIPHENYL-4-ACETIC ACID FELBINAC [1,1'-BIPHENYL]-4-ACETIC ACID Napageln Talc 14807-96-6 Biphenyl monoacetic acid Felbinac Crude 4-Biphenylacetic Methyl Ether 5728-52-9 57285-52-9 572-52-9 40728-52-9 C6H5C6H4CH2CO2H C14H11O2 Organic Building Blocks Building Blocks C13 to C42+ Carbonyl Compounds Carboxylic Acids Aromatics