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3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid

CAS No.
162401-62-9
Chemical Name:
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
Synonyms
RofluM;Roflumilast Impurity J;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Roflumilast USP Related Compound D;Roflumilast Carboxylic Acid Impurity;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID;3-CyclopropylMethoxy-4-isopropoxy-benzoic acid;3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid
CBNumber:
CB02487690
Molecular Formula:
C12H12F2O4
Molecular Weight:
258.22
MDL Number:
MFCD04621687
MOL File:
162401-62-9.mol
MSDS File:
SDS
Last updated:2023-11-08 17:00:29

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Properties

Melting point 118-120℃
Boiling point 356.4±37.0 °C(Predicted)
Density 1.355±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 3.87±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16)
InChIKey IGFDIFLMMLWKKY-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference 162401-62-9

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  2811
HazardClass  6.1
PackingGroup 
HS Code  2918999090
NFPA 704
0
2 0

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000161 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9 1g $104 2024-03-01 Buy
Alfa Aesar H64098 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% 162401-62-9 1g $62.9 2024-03-01 Buy
Alfa Aesar H64098 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% 162401-62-9 5g $241 2024-03-01 Buy
Alfa Aesar H64098 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% 162401-62-9 250mg $20.9 2023-06-20 Buy
TRC C988720 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid 162401-62-9 1g $70 2021-12-16 Buy
Product number Packaging Price Buy
MNO000161 1g $104 Buy
H64098 1g $62.9 Buy
H64098 5g $241 Buy
H64098 250mg $20.9 Buy
C988720 1g $70 Buy

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Chemical Properties,Uses,Production

Uses

An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).

3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 269)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106 sales@trywchem.com China 129 58
Wuhan Quanjinci New Material Co.,Ltd.
+8615271838296 kyra@quanjinci.com China 1532 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Klong Industrial Co., Ltd
0086-519-68231162 info@klongchem.com CHINA 131 58

View Lastest Price from 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid pictures 2023-11-29 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
US $100.00 / kg 1kg 99% 5000000 tons Wuhan Quanjinci New Material Co.,Ltd.
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid pictures 2023-04-20 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
US $0.00-0.00 / kg 5kg 99.99 1ton Hefei TianRui Pharmaceutical Chemical Co., Ltd.
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid pictures 2022-02-10 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
US $0.00 / KG 1KG 99.1% 100 tons Honest Joy Holdings Limited
3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid 3-CyclopropyMethoxy-4-difluoroMethoxy benzoic acid Benzoic acid, 3-(cyclopropylMethoxy)-4-(difluoroMethoxy)- CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID 3-CyclopropylMethoxy-4-isopropoxy-benzoic acid RofluMilast InterMediate II 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, >=98% Roflumilast intermediate B Roflumilast intermediate (3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid) Roflumilast Acid Impurity Roflumilast Impurity J RofluM Roflumilast Carboxylic Acid Impurity Roflumilast USP Related Compound D 162401-62-9 C12H12O4F2 Roflumilast interemdiate Intermediates