3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
- CAS No.
- 162401-62-9
- Chemical Name:
- 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid
- Synonyms
- RofluM;Roflumilast Impurity J;Roflumilast Acid Impurity;Roflumilast intermediate B;RofluMilast InterMediate II;Acid Impurity of Roflumilast;Roflumilast USP Related Compound D;Roflumilast Carboxylic Acid Impurity;CYCLOPROPYL DIFLUOROMETHOXYBENOZOIC ACID;3-CyclopropylMethoxy-4-isopropoxy-benzoic acid
- CBNumber:
- CB02487690
- Molecular Formula:
- C12H12F2O4
- Molecular Weight:
- 258.22
- MDL Number:
- MFCD04621687
- MOL File:
- 162401-62-9.mol
- MSDS File:
- SDS
| Melting point | 118-120℃ |
|---|---|
| Boiling point | 356.4±37.0 °C(Predicted) |
| Density | 1.355±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.87±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C12H12F2O4/c13-12(14)18-9-4-3-8(11(15)16)5-10(9)17-6-7-1-2-7/h3-5,7,12H,1-2,6H2,(H,15,16) |
| InChIKey | IGFDIFLMMLWKKY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 |
| CAS DataBase Reference | 162401-62-9 |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000161 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | 162401-62-9 | 1g | $104 | 2024-03-01 | Buy |
| Alfa Aesar | H64098 | 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% | 162401-62-9 | 1g | $62.9 | 2024-03-01 | Buy |
| Alfa Aesar | H64098 | 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% | 162401-62-9 | 5g | $241 | 2024-03-01 | Buy |
| Alfa Aesar | H64098 | 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid, 98% | 162401-62-9 | 250mg | $20.9 | 2023-06-20 | Buy |
| TRC | C988720 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid | 162401-62-9 | 1g | $70 | 2021-12-16 | Buy |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Chemical Properties,Uses,Production
Description
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) is a pharmaceutical intermediate ingredient used in the preparation of Roflumilast, a selective phosphodiesterase-4 (PDE4) inhibitor approved for the treatment of chronic bronchitis and to reduce the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).
Uses
An impurity and intermediate in the preparation of selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).
Biological Activity
It was shown that 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid (DGM) attenuated transforming growth factor-β1 (TGF-β1)-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. DGM treatment suppressed the expression of proteins such as α-SMA, waveform protein and collagen I and other proteins and increased the expression of E-cadherin. Correspondingly, the phosphorylation level of Smad2/3 was significantly reduced after DGM treatment[1].
Synthesis
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid is synthesised using 3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde as raw material by chemical reaction. The specific synthesis steps are as follows:
3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (12 g, 50 mmol) and sulfamic acid (7.3 g, 75 mmol) were dissolved in glacial acetic acid (50 ml) and the solution added with a solution of sodium chlorite (8.2 g, 75 mmol) in water (15 ml).
The reaction mixture was stirred at room temperature for 1 hr then water (300 ml) was added so obtaining the precipitation of a solid that was filtered and dried at 40° C. under vacuum (12 g, 48 mmol, 97percent yield).
References
[1] TIANXIAO SUN. Inhibitory Effects of 3-Cyclopropylmethoxy-4-(difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo.[J]. International Journal of Molecular Sciences, 2023. DOI:10.3390/ijms24076172.
3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 129 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1534 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18629 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9355 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-23 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
|
US $100.00 / kg | 1kg | 99% | 5000000 tons | Wuhan Quanjinci New Material Co.,Ltd. | |
 |
2023-04-20 | 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
|
US $0.00-0.00 / kg | 5kg | 99.99 | 1ton | Hefei TianRui Pharmaceutical Chemical Co., Ltd. | |
 |
2022-02-10 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
|
US $0.00 / KG | 1KG | 99.1% | 100 tons | Honest Joy Holdings Limited
|
-
- 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
- US $100.00 / kg
- 99%
- Wuhan Quanjinci New Material Co.,Ltd.
-
- 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid
162401-62-9
- US $0.00-0.00 / kg
- 99.99
- Hefei TianRui Pharmaceutical Chemical Co., Ltd.
-
- 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid
162401-62-9
- US $0.00 / KG
- 99.1%
- Honest Joy Holdings Limited
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