Acetyl Podocarpic Acid Anhydride
- CAS No.
- 344327-48-6
- Chemical Name:
- Acetyl Podocarpic Acid Anhydride
- Synonyms
- Acetylpodocarpic dimer;OUJQRQRBNRGQTC-SPGSYPTKSA-N;Acetyl Podocarpic Acid Anhydride;1-Phenanthrenecarboxylic acid, 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-, anhydride with 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, (1S,4aS,10aR)-
- CBNumber:
- CB02590143
- Molecular Formula:
- C38H46O7
- Molecular Weight:
- 614.77
- MDL Number:
- MOL File:
- 344327-48-6.mol
Acetyl Podocarpic Acid Anhydride price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10007686 | Acetyl Podocarpic Acid Anhydride ≥98% | 344327-48-6 | 1mg | $23 | 2024-03-01 | Buy |
| Cayman Chemical | 10007686 | Acetyl Podocarpic Acid Anhydride ≥98% | 344327-48-6 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 10007686 | Acetyl Podocarpic Acid Anhydride ≥98% | 344327-48-6 | 10mg | $177 | 2024-03-01 | Buy |
| Cayman Chemical | 10007686 | Acetyl Podocarpic Acid Anhydride ≥98% | 344327-48-6 | 50mg | $765 | 2024-03-01 | Buy |
| ApexBio Technology | C3042 | AcetylPodocarpicAcidAnhydride | 344327-48-6 | 50mg | $874 | 2021-12-16 | Buy |
Acetyl Podocarpic Acid Anhydride Chemical Properties,Uses,Production
Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols.1 Acetyl podocarpic acid anhydride (APD) is a potent, semisynthetic LXR agonist derived from extracts of the mayapple. APD acting through LXR in concert with the retinoid X receptor (RXR), its heterodimerization partner, induces the expression of the ABCA1 reverse cholesterol transporter.2 This acts to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 value of 1 nM).3 In transient transactivation assays, APD was found to be approximately 1,000 times more potent and have 8-10-fold greater maximal stimulation of LXR than 22(R)-hydroxy cholesterol.3,4 APD can be used as a positive control for the testing of LXR agonists, which have potential as therapeutic agents for the treatment of atherosclerosis.
Definition
ChEBI: Acetyl Podocarpic Acid Anhydride is a diterpenoid.
References
1. Repa, J.J., Turley, S.D., Lobaccaro, J.M.A., et al. Regulation of absorption and ABC1-
2. Costet, P., Luo, Y., Wang, N., et al. Sterol-
3. Sparrow, C.P., Baffic, J., Lam, M.H., et al. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux J. Biol. Chem. 277(12),10021-10027(2002).
4. Singh, S.B., Ondeyka, J.G., Liu, W., et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters Bioorg. Med. Chem. Lett. 15(11),2824-2828(2005).
Acetyl Podocarpic Acid Anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
Acetyl Podocarpic Acid Anhydride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| RD International Technology Co., Limited | 58 |
| ApexBio Technology | 58 |