AMD 3465
- CAS No.
- 185991-24-6
- Chemical Name:
- AMD 3465
- Synonyms
- 1G,10G,100G,1KG;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine;2-Pyridinemethanamine, N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-
- CBNumber:
- CB02685917
- Molecular Formula:
- C24H38N6
- Molecular Weight:
- 410.6
- MDL Number:
- MFCD27955785
- MOL File:
- 185991-24-6.mol
Melting point | 200-205 °C (decomp) |
---|---|
Boiling point | 571.3±50.0 °C(Predicted) |
Density | 1.022±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Powder |
pka | 10.30±0.20(Predicted) |
FDA UNII | IMD9Z48ZTT |
AMD 3465 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A614400 | AMD8664 | 185991-24-6 | 2.5mg | $180 | 2021-12-16 | Buy |
ApexBio Technology | B3395 | AMD3465 | 185991-24-6 | 50mg | $567 | 2021-12-16 | Buy |
ApexBio Technology | B3395 | AMD3465 | 185991-24-6 | 100mg | $914 | 2021-12-16 | Buy |
ApexBio Technology | B3395 | AMD3465 | 185991-24-6 | 5mg | $123 | 2021-12-16 | Buy |
ApexBio Technology | B3395 | AMD3465 | 185991-24-6 | 10mg | $156 | 2021-12-16 | Buy |
AMD 3465 Chemical Properties,Uses,Production
Uses
AMD 8664 is a potent and selective CXCR4 antagonist. CXCR4 antagonists are therapeutic potentials for the treatment of HIV.
Biological Activity
cxcr4 is widely expressed in multiple cell types, and involved in neonatal development, hematopoiesis, and lymphocyte trafficking and homing. additionally cxcr4 is a co-receptor for hiv. small molecule antagonists of cxcr4 thus have therapeutic potential. amd3465 is an n-pyridinylmethylene monocyclam cxcr4 antagonist blocking infection of t-tropic, cxcr4-using hiv.
in vitro
using the ccrf-cem t-cell line expressing cxcr4 previous authors have demonstrated that amd3465 is an antagonist of sdf-1 ligand binding, and inhibits sdf-1 mediated signaling as shown by inhibition of gtp binding, calcium flux, and inhibition of chemotaxis. amd3465 does not inhibit chemokine-stimulated calcium flux in cells expressing cxcr3, ccr1, ccr2b, ccr4, ccr5 or ccr7, nor does it inhibit binding of ltb4 to its receptor, blt1 [1].
in vivo
amd3465 caused leukocytosis when subcutaneously administered in mice and dogs, with peak mobilization occurring between 0.5 and 1.5 h following subcutaneous dosing in mice and with maximum peak plasma concentration of compound preceding peak mobilization in dogs, demonstrating that amd3465 has the potential to mobilize hematopoietic stem cells. these data demonstrate the therapeutic potential for the cxcr4 antagonist amd3465 [1].
IC 50
10.38 ± 1.99 nm for cxcr4 activation as measured by gtp binding
References
[1] bodart v, anastassov v, darkes mc, idzan sr, labrecque j, lau g, mosi rm, neff ks, nelson kl, ruzek mc, patel k, santucci z, scarborough r, wong rs, bridger gj, macfarland rt, fricker sp. pharmacology of amd3465: a small molecule antagonist of the chemokine receptor cxcr4. biochem pharmacol. 2009;78(8):993-1000.
AMD 3465 Preparation Products And Raw materials
Raw materials
Preparation Products
AMD 3465 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |