Protoporphyrin IX
- CAS No.
- 553-12-8
- Chemical Name:
- Protoporphyrin IX
- Synonyms
- PPIX;PROTOPORPHYRIN;ZINC PROTOPORPHYRIN;ZINC PROTOPORPHYRIN-9;ZINC PROTOPORPHYRIN IX;2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-;ZNPP-9;185646;OOPORPHYRIN;PROTOPORPHYRIN-9
- CBNumber:
- CB0723565
- Molecular Formula:
- C34H34N4O4
- Molecular Weight:
- 562.66
- MDL Number:
- MFCD00151109
- MOL File:
- 553-12-8.mol
- MSDS File:
- SDS
| Melting point | >300 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 629.06°C (rough estimate) |
| Density | 1.1829 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly) |
| form | Powder |
| color | purple |
| Water Solubility | 106.9mg/L(25 ºC) |
| Sensitive | light sensitive |
| Merck | 13,7990 |
| BRN | 380795 |
| Stability | Light Sensitive |
| InChIKey | FEDYMSUPMFCVOD-UJJXFSCMSA-N |
| CAS DataBase Reference | 553-12-8 |
| EWG's Food Scores | 1 |
| FDA UNII | C2K325S808 |
| NIST Chemistry Reference | Protoporphyrin-1x(553-12-8) |
| EPA Substance Registry System | Protoporphyrin IX (553-12-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 8-10-23 |
Protoporphyrin IX price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P8293 | Protoporphyrin IX ≥95% | 553-12-8 | 1g | $130 | 2024-03-01 | Buy |
| Strem Chemicals | 07-1820 | Protoporphyrin IX | 553-12-8 | 250mg | $91 | 2024-03-01 | Buy |
| Strem Chemicals | 07-1820 | Protoporphyrin IX | 553-12-8 | 1g | $267 | 2024-03-01 | Buy |
| Usbiological | 257164 | Zinc protoporphyrin IX | 553-12-8 | 10mg | $375 | 2021-12-16 | Buy |
| TRC | P839138 | Protoporphyrin-9 | 553-12-8 | 100mg | $80 | 2021-12-16 | Buy |
Protoporphyrin IX Chemical Properties,Uses,Production
Uses
hepatoprotectant
Uses
Protoporphyrin IX has been used:
- as a standard in protoporphyrin assays
- in fluorescence spectra analysis
- to treat cells in cell culture to study heme-mediated ferroportin 1 transcription
Definition
ChEBI: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyri s.
General Description
Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.
Biochem/physiol Actions
Protoporphyrin IX?levels are elevated in?tumor?cells due to?metabolism anomalies?compared to normal?cells.
Enzyme inhibitor
This iiron-free, immediate precusor of heme (FWfree-acid = 562.67 g/mol; CAS 553-12-8; brownish-yellow solid; soluble in a number of organic solvents; disodium and dipotassium salts solublized in the presence of Tween 80) has lmax values in 25% HCl are 602.4, 582.2, and 557.2 nm. Protoporphryrin IX is also an activator of guanylate cyclase. See also Iron Protoporphyrin IX; Heme; Hemin Target(s): aminolevulinate aminotransferase; 5-aminolevulinate synthase; glutamate: glyoxylate aminotransferase; glutathione S-transferase; glyoxalase I, or lactoylglutathione lyase; guanylate cyclase; heme oxygenase; hydroxymethylbilane synthase, or porphobilinogen deaminase; nitric-oxide synthase; porphobilinogen synthase, or 5-aminolevulinate dehydratase; succinyl-CoA synthetase; tryptophan pyrrolase, or tryptophan 2,3-dioxygenase; and uroporphyrinogen decarboxylase.
Purification Methods
Protoporphyrin IX (3,18-divinyl-2,7,13,17-tetramethylporphin-8,12-dipropionic acid, ooporphyrin) [553-12-8] M 562.7, pKEst ~ 4.8. Protoporphyrin IX is purified by dissolving (4g) in 98-100% HCOOH (85mL), diluting with dry Et2O (700mL) and keeping at 0o overnight. The precipitate is collected and washed with Et2O, then H2O, and dried in a vacuum at 50o over P2O5. It crystallises from aqueous pyridine and from Et2O in monoclinic, brownish-yellow prisms. The UV max values in 25% HCl are 557.2, 582.2 and 602.4nm. It is freely soluble in ethanolic HCl, AcOH, CHCl3, and Et2O containing AcOH. It forms sparingly soluble diNa and diK salts. [Ramsey Biochemical Preparations 3 39 1953, UV: Holden Aust J. Exptl Biol and Med Sci 15 412 1937, Garnick J Biol Chem 175 333 1948, IR: Falk & Willis Aust J Sci Res [A] 4 579 1951, Beilstein 26 IV 3042.]
Toxicity evaluation
protoporphyrin IX, is highly toxic in the presence of light and molecular oxygen, killing photosynthetic plants very quickly through the generation of singlet oxygen.
Protoporphyrin IX Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Protoporphyrin IX manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-16 | Protoporphyrin IX
553-12-8
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-10-16 | Protoporphyrin IX
553-12-8
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-06-15 | Protoporphyrin IX
553-12-8
|
US $110.00 / g | 10g/Bag | 99 | 10KG | Baoji Guokang Bio-Technology Co., Ltd. |
-
- Protoporphyrin IX
553-12-8
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Protoporphyrin IX
553-12-8
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Protoporphyrin IX
553-12-8
- US $110.00 / g
- 99
- Baoji Guokang Bio-Technology Co., Ltd.
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