ChemicalBook >> CAS DataBase List >>4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE structure

CAS No.: 652968-37-1

Chemical Name:: 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

Synonyms: MITOPBN;4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE

CBNumber:: CB0821515

Molecular Formula:: C33H37BrNO2P

Molecular Weight:: 590.54

MDL Number:: MFCD09037545

MOL File:: Mol file

Last updated:2023-05-21 10:59:17

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4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Properties

storage temp.	Store at -20°C
solubility	DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml
form	A solid

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18809	MitoPBN ≥95%	652968-37-1	10mg	$421	2024-03-01	Buy
AK Scientific	8604DU	N-Tert-Butyl{4-[4-(triphenylphosphaniumyl)butoxy]phenyl}methanimineN-oxidebromide	652968-37-1	10mg	$565	2021-12-16	Buy

Product number	Packaging	Price	Buy
18809	10mg	$421	Buy
8604DU	10mg	$565	Buy

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Chemical Properties,Uses,Production

Description

MitoPBN is a mitochondria-targeted antioxidant.¹ It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC₅₀ = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

References

1. Murphy, M.P., Echtay, K.S., Blaikie, F.H., et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert-butylnitrone J. Biol. Chem. 278(49),48534-48545(2003).

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7984	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48467	58

Supplier	Advantage
Aladdin Scientific	58
Shanghai Hongye Biotechnology Co. Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58

4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE MITOPBN 652968-37-1