Quinapril | 85441-61-8

Quinapril Properties

Melting point	120-130°C
Boiling point	662.0±55.0 °C(Predicted)
Density	1.217±0.06 g/cm3(Predicted)
pka	3.39±0.20(Predicted)
BCS Class	1
CAS DataBase Reference	85441-61-8(CAS DataBase Reference)
FDA UNII	RJ84Y44811
ATC code	C09AA06

Pharmacokinetic data

Protein binding	97%
Excreted unchanged in urine	30%
Volume of distribution	1.5(L/kg)
Biological half-life	1 / 12-14

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25

Quinapril price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0005419	QUINAPRIL 95.00%	85441-61-8	5MG	$637.79	2021-12-16	Buy
American Custom Chemicals Corporation	API0005419	QUINAPRIL 95.00%	85441-61-8	50MG	$747.05	2021-12-16	Buy
American Custom Chemicals Corporation	API0005419	QUINAPRIL 95.00%	85441-61-8	100MG	$886.53	2021-12-16	Buy
AHH	API-1582	Quinapril 98%	85441-61-8	1g	$710	2021-12-16	Buy
AvaChem	1632B	Quinapril	85441-61-8	100mg	$35	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0005419	5MG	$637.79	Buy
API0005419	50MG	$747.05	Buy
API0005419	100MG	$886.53	Buy
API-1582	1g	$710	Buy
1632B	100mg	$35	Buy

Quinapril Chemical Properties,Uses,Production

Description

Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the treatment of essential hypertension. The main claimed advantage of quinapril compared with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure.

Originator

Warner-Lambert (USA)

Uses

Antihypertensive; enzyme inhibitor (angiotensin-converting).

Definition

ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) ;Accupro.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Quniapril is a prodrug which is metabolised in the liver to its active form, quinaprilat, and to minor inactive metabolites.
Quinaprilat is eliminated primarily by renal excretion.

Quinapril Preparation Products And Raw materials

Raw materials

Benzyl ester Trifluoroacetic acid Acetic acid Quinapril hydrochloride Quinazoline

Preparation Products

Quinapril Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9231	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58

Supplier	Advantage
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58

View Lastest Price from Quinapril manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	Quinapril 85441-61-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-05-10	Quinapril 85441-61-8	US $0.00-0.00 / Kg	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	Quinapril 85441-61-8	US $1.00 / kg	1kg	95%-99%	10kg	Career Henan Chemical Co

Quinapril
85441-61-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Quinapril
85441-61-8
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

Quinapril
85441-61-8
US $1.00 / kg
95%-99%
Career Henan Chemical Co

85441-61-8(Quinapril)Related Search:

Propyl butyrate 5,6,7,8-TETRAHYDROISOQUINOLINE Propyl gallate Phenylhydrazine Isoquinoline

PHENYL VALERATE Quinapril benzyl ester maleate Carbonyl iron powder Quinapril hydrochloride Isoquinoline-1-carboxylic acid

N-[S-(2-PYRIDYLTHIO)CYSTEAMINYL]ETHYLENEDIAMINE-N,N,N',N'-TETRAACETIC ACID, MONOAMIDE QUINAPRIL RELATED COMPOUND A ETHYL[3S-[2(R*),3A,11A BETA]]-1,3,4,6,11,11A-HEXAHYDRO-3-METHYL-1,4-DIOXO-ALPHA-(2-PHENYLETHYL)-2H-PYRAZINO[1,2-B]ISOQUINOLINE-2-ACETATE USP QUINAPRILAT Quinapril

1of3

QUINAPRIL HCL PD-109452-2 CI-906 (3S)-2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid (S)-2-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ACCUPRIL ACCUPRIN ACCUPRO 2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (3s-(2(r*(r*)),3r*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride (3S)-2-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE Asig S-1,2,3,4CTetrahydro-3-IsoquinolinecarboxylicAcid Quniapril 3-Isoquinolinecarboxylic acid, 2-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyl-1,2,3,4-tetrahydro-, (3S)- 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)- (9CI) 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]- Ectren Koretic [3S-[2[R^<*>^ (R^<*>^)]，3R^<*>^]]-2-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1，2，3，4-tetrahydro-3-isoquinolinecarboxylic acid Acequin：Acuitel Korec：Quinazil (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (3S)-2-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid Quinapril (3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid JSDRRTOADPPCHY-HSQYWUDLSA-N (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Quinapril USP/EP/BP 85441-61-8 84551-61-8 C25H30N2O5