Dmophebumine
- CAS No.
- 3735-45-3
- Chemical Name:
- Dmophebumine
- Synonyms
- Revatrine;Vetrabutine;Dmophebumine;N,N-Dimethyl-α-(3-phenylpropyl)veratrylamine;1-(3,4-Dimethoxyphenyl)-4-phenylbutyldimethylamine;Benzenebutanamine, α-(3,4-dimethoxyphenyl)-N,N-dimethyl-;1-(3,4-dimethoxyphenyl)-N,N-dimethyl-4-phenylbutan-1-amine;1-(3,4-dimethoxyphenyl)-N,N-dimethyl-4-phenyl-butan-1-amine
- CBNumber:
- CB11178558
- Molecular Formula:
- C20H27NO2
- Molecular Weight:
- 313.438
- MDL Number:
- MOL File:
- 3735-45-3.mol
| Boiling point | bp0.1 166-168° |
|---|---|
| Density | 1.027±0.06 g/cm3(Predicted) |
| pka | 8.54±0.50(Predicted) |
| FDA UNII | I3E2J32F37 |
Dmophebumine Chemical Properties,Uses,Production
Originator
Monzal ,Boenhringer Ingelheim
Definition
ChEBI: Vetrabutine is a member of benzenes and an organic amino compound.
Manufacturing Process
1.5 mole magnesium and 1 mole 3-phenylpropyl bromide were used for preparing of ester solution of Grignar reagent. 1 mole (3,4- dimethoxyphenyl)dimethylaminoacetonitrile in absolute ester was added to above reagent dropwise. Then the mixture was heated for 3 hours to reflux. On cooling it was poured into ice with 12% hydrochloric acid. The ester layer was separated. The water layer was alkalized with concentrate ammonia and ammonium chloride. The precipitated oil was dissolved in ester, dried over sodium sulfate and distilled in vacuum after removing of ester to give α-(3,4- dimethoxyphenyl)-N,N-dimethylbenzenebutanamine (vertabutine); BP: 166°- 168°C/0.1 mm Hg. Yield 85%. The free base may be turn into colorless hydrochloride by adding of equivalent of hydrochloric acid in ester; MP: 146°- 148°C.
Therapeutic Function
Uterine relaxant
Dmophebumine Preparation Products And Raw materials
Dmophebumine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Supplier | Advantage |
|---|---|
| Career Henan Chemica Co | 58 |