METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- CAS No.
- 1499-29-2
- Chemical Name:
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- Synonyms
- bis(dichlorophosphoryl)methane;BIS(DICHLOROPHOSPHONYL)METHANE;Bis-(dichlorophosphinyl)-methane;METHYLENEDIPHOSPHONIC DICHLORIDE;Methylenedisphosphonic Dichloride;METHYLENEBIS(PHOSPHONIC DICHLORIDE);Phosphonic dichloride, P,P'-methylenebis-
- CBNumber:
- CB1147951
- Molecular Formula:
- CH2Cl4O2P2
- Molecular Weight:
- 249.78
- MDL Number:
- MFCD00013901
- MOL File:
- 1499-29-2.mol
- MSDS File:
- SDS
| Melting point | 102-104 °C(lit.) |
|---|---|
| Boiling point | 329.0±25.0 °C(Predicted) |
| Density | 1.798±0.06 g/cm3(Predicted) |
| solubility | Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly) |
| form | crystalline powder |
| color | Faint beige |
| Stability | Moisture Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 |
| Hazard Codes | C |
| Risk Statements | 14-34 |
| Safety Statements | 26-27-36/37/39-45 |
| RIDADR | UN 3261 8/PG 1 |
| WGK Germany | 3 |
| HS Code | 2931599090 |
METHYLENEBIS(PHOSPHONIC DICHLORIDE) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 447714 | Methylenebis(phosphonic dichloride) 97% | 1499-29-2 | 5g | $163 | 2024-03-01 | Buy |
| TRC | M304305 | Methylenebis(phosphonic dichloride) | 1499-29-2 | 1g | $140 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | OGM0001314 | METHYLENEBIS(PHOSPHONIC DICHLORIDE) 95.00% | 1499-29-2 | 1G | $247.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | OGM0001314 | METHYLENEBIS(PHOSPHONIC DICHLORIDE) 95.00% | 1499-29-2 | 5G | $906.05 | 2021-12-16 | Buy |
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Chemical Properties,Uses,Production
Description
Methylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.
Chemical Properties
Crystals of the Methylenebis(phosphonic dichloride) are monoclinic, space group C2/c, with a= 15·866(5), b= 5·845(1), c= 9·161 (3)A, β= 106·59(2)°, Z= 4. The molecules, which display a crystallographically imposed C2 symmetry, are linked together through two C–H ? O(P) hydrogen bonds, of length 3·23(1)A, into infinite chains in the z direction. Rigid-body analysis reveals that pronounced rotational and translational motions are associated with the axis of minimum inertia and least cross-section. Bond lengths (corrected for libration) are: P–Cl 1·994(2) and 1·997 (2), PO 1·463(4), P–C 1·804(4)A; angle P–C–P 116·4(4)°, the structure was solved by direct methods and refined by full-matrix least-squares to R 0·041 for 641 diffractometer-measured unique reflections[1].
Uses
Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.
Application
Methylenebis (phosphonic dichloride) can be used for the following studies:
(1) Synthesis of mycophenolic methylenebis(phosphonate) derivatives.
(2) Phosphonylation of nucleosides.
(3) Preparation of P,P′-partial esters of methylenebisphosphonic acid.
(4) Synthesis of symmetrical di- and tetra- esters of methylenebisphosphonic acid.
References
[1] SHELDRICK W. Crystal structure of methylenebis(phosphonic dichloride)[J]. Journal of The Chemical Society-dalton Transactions, 1975. DOI:10.1039/DT9750000943.
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Preparation Products And Raw materials
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ROSEWA HOLDING GROUP CO.,LIMITED | +86-023-62871537 | sales@rosewachem.com | China | 2830 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7934 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3371 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
View Lastest Price from METHYLENEBIS(PHOSPHONIC DICHLORIDE) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-23 | METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
|
US $50.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2022-09-03 | METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1000kg | ROSEWA HOLDING GROUP CO.,LIMITED | |
 |
2021-11-15 | METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
|
US $50.00 / KG | 1KG | 99% | 500ton/Month | Qiuxian Baitai New Material Co., LTD |
-
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
- US $50.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
- US $0.00-0.00 / kg
- 98%
- ROSEWA HOLDING GROUP CO.,LIMITED
-
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
1499-29-2
- US $50.00 / KG
- 99%
- Qiuxian Baitai New Material Co., LTD