Genz644282
- CAS No.
- 529488-28-6
- Chemical Name:
- Genz644282
- Synonyms
- CS-1079;GNZ-644282;Genz644282;GNZ-644282cas;GENZ644282; GENZ 644282;GENZ-644282;GENZ644282;GENZ 644282;Genz 644282,Inhibitor,inhibit,Genz-644282,Topoisomerase;8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one;2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one;Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 2,3-dimethoxy-12-[2-(methylamino)ethyl]-
- CBNumber:
- CB12627899
- Molecular Formula:
- C22H21N3O5
- Molecular Weight:
- 407.42
- MDL Number:
- MFCD25976816
- MOL File:
- 529488-28-6.mol
- MSDS File:
- SDS
| Melting point | 254-257℃ (Decomposition) |
|---|---|
| Boiling point | 665.5±55.0 °C(Predicted) |
| Density | 1.344±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 9.59±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | 717I541I2R |
Genz644282 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 5mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 10mg | $351 | 2024-03-01 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 25mg | $728 | 2024-03-01 | Buy |
| TRC | G367760 | GENZ-644282 | 529488-28-6 | 50mg | $1215 | 2021-12-16 | Buy |
Genz644282 Chemical Properties,Uses,Production
Uses
GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.
Uses
GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.
Biological Activity
genz-644282 [8,9-dimethoxy-5-(2-n-methylaminoethyl)-2,3-methylenedioxy-5h-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate of non-camptothecin topoisomerase i inhibitor for antitumor agents.
in vitro
genz-644282 demonstrated potent cytotoxic activity with a median ic(50) of 1.2 nm (range 0.2-21.9 nm) [1]. limited cross-resistance to genz-644282 was also found in the top1 knockdown colon cancer (hct116) and breast cancer (mcf7) cell lines and in human adenocarcinoma cells (kb31/kbv1) that overexpress (p-glycoprotein, abcb1), a member of the atp-binding cassette family of cell surface transport proteins known to confer mdr [3].
in vivo
genz-644282 at its mtd (4 mg/kg) induced maintained complete responses (mcr) in 6/6 evaluable solid tumor models. at 2 mg/kg genz-644282 induced cr or mcr in 3/3 tumor models relatively insensitive to topotecan, but there were no objective responses at 1 mg/kg [1]. genz-644282 was tolerated at doses up to 4 mg/kg when administered intravenously on alternate days, and the compound was active at doses from 1 to 4 mg/kg. the efficacy of genz-644282 was compared with irinotecan in 4 human colon carcinoma xenograft models. in the human hct-116 colon cancer xenograft, tgd values were 14 days for irinotecan (60 mg/kg) and 34 days for genz-644282 (2.7 mg/kg), giving maximum test to control ratios (t/cs) of 23.7% and 16.8%, respectively [2].
IC 50
1.2 nm [1]
Genz644282 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
View Lastest Price from Genz644282 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | Genz644282
529488-28-6
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
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- Genz644282
529488-28-6
- US $1.00 / g
- 99%
- Career Henan Chemical Co