ChemicalBook >> CAS DataBase List >>P-5091
P-5091
- CAS No.
- 882257-11-6
- Chemical Name:
- P-5091
- Synonyms
- P5091;P 5091;P-5091;CS-726;P005091;P-005091;P 005091;P5091, >=98%;P005091(P5091);P5091 (P005091)
- CBNumber:
- CB12668070
- Molecular Formula:
- C12H7Cl2NO3S2
- Molecular Weight:
- 348.22
- MDL Number:
- MFCD00123202
- MOL File:
- 882257-11-6.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:02:15
| Boiling point | 452.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.60±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | light yellow to dark yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
P-5091 price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0770 | P5091 ≥98% (HPLC) | 882257-11-6 | 5mg | $134 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0770 | P5091 ≥98% (HPLC) | 882257-11-6 | 25mg | $435 | 2024-03-01 | Buy |
| Cayman Chemical | 15224 | P005091 ≥98% | 882257-11-6 | 5mg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 15224 | P005091 ≥98% | 882257-11-6 | 10mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 15224 | P005091 ≥98% | 882257-11-6 | 25mg | $228 | 2024-03-01 | Buy |
P-5091 Chemical Properties,Uses,Production
Description
P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable
Uses
P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.
Uses
P5091 has been used:
- as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
- as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
- as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
Biochem/physiol Actions
P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
References
1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345 2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789
P-5091 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 93)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28761 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
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882257-11-6
C12H7Cl2NO3S2
Inhibitors