4-(di(1H-indol-3-yl)Methyl)phenol
- CAS No.
- 151358-47-3
- Chemical Name:
- 4-(di(1H-indol-3-yl)Methyl)phenol
- Synonyms
- C-DIM8;DIM-C-pPhOH;DIM-C-pPhOH(CDIM8);4-(di(1H-indol-3-yl)Methyl)phenol;4-[bis(1H-indol-3-yl)methyl]phenol;Phenol, 4-(di-1H-indol-3-ylmethyl)-;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
- CBNumber:
- CB12682261
- Molecular Formula:
- C23H18N2O
- Molecular Weight:
- 338.4
- MDL Number:
- MFCD03723253
- MOL File:
- 151358-47-3.mol
| Melting point | 122-124 °C |
|---|---|
| Boiling point | 610.2±50.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml) |
| form | solid |
| pka | 9.98±0.26(Predicted) |
| color | Pink |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
4-(di(1H-indol-3-yl)Methyl)phenol price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6377 | DIM-C-pPhOH ≥98%(HPLC) | 151358-47-3 | 5 | $95 | 2021-12-16 | Buy |
| Tocris | 6377 | DIM-C-pPhOH ≥98%(HPLC) | 151358-47-3 | 25 | $371 | 2021-12-16 | Buy |
| Matrix Scientific | 105340 | 4-(Di(1H-indol-3-yl)methyl)phenol | 151358-47-3 | 2g | $975 | 2021-12-16 | Buy |
| Chemenu | CM265482 | 4-(Di(1H-indol-3-yl)methyl)phenol 95%+ | 151358-47-3 | 5g | $1234 | 2021-12-16 | Buy |
| Alichem | 151358473 | 4-(Di(1H-indol-3-yl)methyl)phenol | 151358-47-3 | 5g | $1306.8 | 2021-12-16 | Buy |
4-(di(1H-indol-3-yl)Methyl)phenol Chemical Properties,Uses,Production
Description
C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5
storage
Store at -20°C
References
Chintharlapalli et al. (2005), Activation of Nur77 by selected 1,1-Bis(3’-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways; J. Biol. Chem., 280 24903 Lee et al. (2014), The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells; Mol. Cancer Res., 12 527 Lee et al. (2012), The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53; Oncogene, 31 3265 Hedrick et al. (2016), NR4A1 Antagonists Inhibit ?1-Integrin-Dependent Breast Cancer Cell Migration; Mol. Cell. Biol., 36 1383 Shrestha et al. (2021), The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells; Mol. Cancer Ther. 20 612
4-(di(1H-indol-3-yl)Methyl)phenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2606 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Candia Pharmatech Co. , Ltd. | +86-371-55216238 | China | 286 | 60 |