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Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate structure

CAS No.: 1392275-56-7

Chemical Name:: Tenofovir alafenamide hemifumarate

Synonyms: Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate

CBNumber:: CB13038481

Molecular Formula:: C25H33N6O9P

Molecular Weight:: 592.55

MDL Number:: MFCD30534429

MOL File:: 1392275-56-7.mol

Last updated:2024-04-25 17:59:01

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Tenofovir alafenamide hemifumarate Properties

storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
CAS DataBase Reference	1392275-56-7
FDA UNII	FWF6Q91TZO

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Tenofovir alafenamide hemifumarate price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-6112	Tenofoviralafenamidehemifumarate 99.79%	1392275-56-7	5mg	$50	2021-12-16	Buy
ChemScene	CS-6112	Tenofoviralafenamidehemifumarate 99.79%	1392275-56-7	10mg	$70	2021-12-16	Buy
ChemScene	CS-6112	Tenofoviralafenamidehemifumarate 99.79%	1392275-56-7	50mg	$140	2021-12-16	Buy
ChemScene	CS-6112	Tenofoviralafenamidehemifumarate 99.79%	1392275-56-7	100mg	$190	2021-12-16	Buy
AK Scientific	V9722	Tenofoviralafenamidehemifumarate	1392275-56-7	5g	$338	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-6112	5mg	$50	Buy
CS-6112	10mg	$70	Buy
CS-6112	50mg	$140	Buy
CS-6112	100mg	$190	Buy
V9722	5g	$338	Buy

Tenofovir alafenamide hemifumarate Chemical Properties,Uses,Production

Description

Tenofovir alafenamide hemifumarate is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

Chemical Properties

White to almost White crystal or crystalline powder.

Originator

Gilead Sciences

Uses

Tenofovir alafenamide hemifumarate is a newer, more effective prodrug used in combination with FTC that has recently been approved for the prevention of HIV transmission through the rectum. It is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.

Definition

ChEBI: A fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection.

Clinical Use

Tenofovir alafenamide hemifumarate is useful in the treatment and/or prophylaxis of one or more viral infections in man or animals, including infections caused by DNA viruses. RNA viruses, herpesviruses (e.g., CMV, HSV 1, HSV 2, VZV), retroviruses, hepadnaviruses (e.g., HBV), papillomavirus, hantavirus, adenoviruses and HIV. Like tenofovir disoproxil, tenofovir alafenamide is another prodrug form of tenofovir, and can be used in the treatment and/or prophylaxis of the same conditions.

Side effects

Check with your doctor immediately if any of the following side effects occur:
Abdominal or stomach discomfort,bloody urine,dark urine,decreased appetite,decreased frequency or amount of urine,troubled breathing,cough,headache,back pain.

Synthesis

Under a nitrogen atmosphere, 200 g of isopropanol, 9 g of fumaric acid, and 50 g of TAF-3 were sequentially added to a 2 L reaction flask. Turn on the stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, filter while hot, collect the mother liquor. Transfer the mother liquor to a 2L reaction bottle, start stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, slowly reduce the temperature to 0 ~ 5 ° C, cooling time 2 ~ 3 hours, heat stirring for 10 hours. Filtration, drying at 60-65 ° C for 12 to 16 hours, to obtain 37.5 g of Tenofovir Alafenamide Fumarate finished product, white powder, yield 75.0%.

Drug interactions

Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).

Advantages

One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.

Tenofovir alafenamide hemifumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Tenofovir alafenamide hemifumarate Suppliers

Global( 308)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.	+86-0086-531-88259693 +86-18660188356	maguanglei@zisonpharm.com	China	53	58
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	tinayang@enbridgepharm.com	China	303	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	+8615065888978	admin@hsnordpharma.com	China	92	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	902	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55

Supplier	Advantage
Zison Pharmaceutical (Shandong) Co., Ltd.	58
ENBRIDGE PHARMTECH CO., LTD.	58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.	58
AFINE CHEMICALS LIMITED	58
Sinoway Industrial co., ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55

The preparation of tenofovir alafenamide fumarate
Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue re....
Sep 5，2022

View Lastest Price from Tenofovir alafenamide hemifumarate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-28	Tenofovir alafenamide hemifumarate 1392275-56-7	US $1050.00-1000.00 / kilograms	10kilograms	99%	100ton	Hebei Dangtong Import and export Co LTD
2024-04-25	Tenofovir Alafenamide Fumarate 1392275-56-7	US $0.00 / kg	1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-04-24	Tenofovir Alafenamide Fumarate 1392275-56-7	US $0.00 / kg	1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenofovir alafenamide hemifumarate
1392275-56-7
US $1050.00-1000.00 / kilograms
99%
Hebei Dangtong Import and export Co LTD

Tenofovir Alafenamide Fumarate
1392275-56-7
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Tenofovir Alafenamide Fumarate
1392275-56-7
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

1392275-56-7(Tenofovir alafenamide hemifumarate)Related Search:

Tenofovir Alafenamide Tenofovir Diisopropyl Tenofovir FuMarate 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox P-[[(1S)-2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-phosphonic Acid Monoethyl Ester

Tenofovir Alafenamide Impurity 30 Tenofovir Impurity H (E)-9-(prop-1-en-1-yl)-9H-purin-6-amine Tenofovir Related Compound 6 isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate

TENOFOVIR-D6 Tenofovir Related Compound 1 (((((1-(6-aMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) isopropyl Methyl dicarbonate isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Tenofovir Disopropyl Ethyl Diester

Mono-POC Tenofovir FuMarate Salt ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate Tenofovir disoproxil

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GS-7340 (hemifumarate) Anti-HIV API-Anti-HBV (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1) (R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester Tenofovir alafenamide hemifumarate TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE) Tenofovir levamide amine fumarate (Tenofovir alafenamide : fumarate = 2:1) (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate Tenofovir Alafenamide fumarate [USAN] Alafenamide hemifumarate Tenofovir Alafenamide Hemifumarate(2:1) Tenofovir Alafenamide Fumarate USP/EP/BP Tenofovir Alafenamid Tenofovir Alafenamide Hemifumarate salt[USAN Tenofovir alafenamide hemifumarate (GS-7340) Tenofovir Alafenamide Hemifumarate salt Tenofovir Alafenamide fumarateQ: What is Tenofovir Alafenamide fumarate Q: What is the CAS Number of Tenofovir Alafenamide fumarate L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1) N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1) GS7340(Tenofovir Alafenamide Fumarate) 3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl)- Tenofovir Alafenamide fumarate Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate Tenofovir dipivoxil phenol amine fumarate 2-fluoro-5-[(4' -0x0-3'H-phthalazin-1'-yl)methyllbenzoic acide' Celiprolol Impurity 8(Celiprolol EP Impurity H) Tenofovir Alafenamide Hemifumarate(2:1) CRS Tenofovir Alafenamide Fumarate API 1392275-56-7 C46H62N12O14P2 2C21H29N6O5PC4H4O4 API 1392275-56-7