ChemicalBook >> CAS DataBase List >>FIIN-2
FIIN-2
- CAS No.
- 1633044-56-0
- Chemical Name:
- FIIN-2
- Synonyms
- FIN-2;FIIN-2;CS-1618;FIIN2;FIIN-2;FIIN 2;inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2;N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide;2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
- CBNumber:
- CB13049254
- Molecular Formula:
- C35H38N8O4
- Molecular Weight:
- 634.73
- MDL Number:
- MFCD28386553
- MOL File:
- 1633044-56-0.mol
Last updated:2023-06-08 09:02:45
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
FIIN-2 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19837 | FIIN-2 ≥98% | 1633044-56-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 19837 | FIIN-2 ≥98% | 1633044-56-0 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 19837 | FIIN-2 ≥98% | 1633044-56-0 | 10mg | $278 | 2024-03-01 | Buy |
| Cayman Chemical | 19837 | FIIN-2 ≥98% | 1633044-56-0 | 25mg | $533 | 2024-03-01 | Buy |
| TRC | F336505 | FIIN2 | 1633044-56-0 | 5mg | $275 | 2021-12-16 | Buy |
FIIN-2 Chemical Properties,Uses,Production
Description
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2. By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR.
Uses
FIIN 2 is FGFR inhibitor. It can be used in biological study of DFG-out mode of inhibition by an irreversible Type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors
FIIN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
FIIN-2 Suppliers
Global( 68)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4654 | 58 |
FIN-2
N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide
FIIN-2
2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
CS-1618
FIIN2;FIIN-2;FIIN 2
inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2
1633044-56-0
1533044-56-0
C35H38N8O4