(R,S)-ANATABINE
- CAS No.
- 2743-90-0
- Chemical Name:
- (R,S)-ANATABINE
- Synonyms
- D,L-ANATABINE;rac-Anatabine;(R,S)-ANATABINE;Nicotine USP RC A;ANATABINE, (+/-)-(RG);1,2,3,6-TETRAHYDRO-2,3'-BIPYRIDINE;Nicotine EP Impurity A as Racemate;1,2,3,6-Tetrahydro-2,3'-bipyridine;Anatabine, froM Nicotiana tabacuM L.;2,3'-Bipyridine, 1,2,3,6-tetrahydro-
- CBNumber:
- CB1382628
- Molecular Formula:
- C10H12N2
- Molecular Weight:
- 160.22
- MDL Number:
- MFCD00078278
- MOL File:
- 2743-90-0.mol
Boiling point | 136 |
---|---|
Density | 1.045±0.06 g/cm3(Predicted) |
storage temp. | Amber Vial, Refrigerator, Under Inert Atmosphere |
solubility | ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide |
form | solution in ethanol. |
pka | 8.84±0.40(Predicted) |
color | Light yellow to yellow |
Stability | Hygroscopic, Light Sensitive |
CAS DataBase Reference | 2743-90-0 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301-H319 |
Precautionary statements | P264-P270-P280-P301+P310-P305+P351+P338-P337+P313 |
Risk Statements | 25-36 |
Safety Statements | 24/25 |
RIDADR | 2810 |
HazardClass | IRRITANT |
HS Code | 29399990 |
(R,S)-ANATABINE price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR3060 | Nicotine Related Compound A/EP Impurity A pharmaceutical secondary standard, certified reference material | 2743-90-0 | 50MG | $576 | 2024-03-01 | Buy |
Sigma-Aldrich | 1463326 | Nicotine Related Compound A United States Pharmacopeia (USP) Reference Standard | 2743-90-0 | 20mg | $1380 | 2024-03-01 | Buy |
Cayman Chemical | 11001 | (R,S)-Anatabine ≥95% | 2743-90-0 | 5mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 11001 | (R,S)-Anatabine ≥95% | 2743-90-0 | 10mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 11001 | (R,S)-Anatabine ≥95% | 2743-90-0 | 50mg | $241 | 2024-03-01 | Buy |
(R,S)-ANATABINE Chemical Properties,Uses,Production
Description
(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-
Chemical Properties
Light Yellow Oil
Uses
A nicotine (N412420) metabolite.
Uses
A nicotine metabolite
Uses
(R,S)-Anatabine is a metabolite of Nicotine (N412420).
in vitro
anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].
in vivo
in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].
References
[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.
(R,S)-ANATABINE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Nanjing jinheyou Trading Co., Ltd. | 15705188088 | admin@jheyou.com | CHINA | 1268 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
AFINE CHEMICALS LIMITED | +86-008657185134551 +86-18958018566 | sales@afinechem.com | China | 15394 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
View Lastest Price from (R,S)-ANATABINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-23 | (R,S)-ANATABINE
2743-90-0
|
US $0.00 / g | 1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
- (R,S)-ANATABINE
2743-90-0
- US $0.00 / g
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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