Ryanodine
- CAS No.
- 15662-33-6
- Chemical Name:
- Ryanodine
- Synonyms
- Ryanex;ryania;RYANADOL;ryanexel;Ryanexcel;Ryanicide;RYANODINE;bonideryatox;ryaniapowder;Ryanodine,99%
- CBNumber:
- CB1480087
- Molecular Formula:
- C25H35NO9
- Molecular Weight:
- 493.55
- MDL Number:
- MFCD00151119
- MOL File:
- 15662-33-6.mol
- MSDS File:
- SDS
| alpha | D25 +26° (methanol) |
|---|---|
| Boiling point | 586.95°C (rough estimate) |
| Density | 1.2805 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | White solid |
| Melting point | 219-220 °C |
| pka | 10.66±0.70(Predicted) |
| color | white to beige |
| CAS DataBase Reference | 15662-33-6 |
| FDA UNII | 37H6ATE4SA |
| EPA Substance Registry System | Ryanodine (15662-33-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312-H410 |
| Precautionary statements | P264-P270-P273-P280-P301+P312-P302+P352+P312 |
| Hazard Codes | Xn,N |
| Risk Statements | 21/22-50/53 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9/PG 3 |
| RTECS | VM4025000 |
Ryanodine price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 559276 | Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum. | 15662-33-6 | 500μg | $265 | 2024-03-01 | Buy |
| Tocris | 1329 | Ryanodine ≥98%(HPLC) | 15662-33-6 | 1 | $214 | 2021-12-16 | Buy |
| Usbiological | 256544 | Ryanodine | 15662-33-6 | 1mg | $466 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR30087 | Ryanodine | 15662-33-6 | 1mg | $700 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR30087 | Ryanodine | 15662-33-6 | 2mg | $1100 | 2021-12-16 | Buy |
Ryanodine Chemical Properties,Uses,Production
Description
Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).
Chemical Properties
white to off-white solid
Uses
Insecticide.
Uses
Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.
Definition
ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.
Biological Activity
Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
storage
-20°C (desiccate)
References
Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)
Ryanodine Preparation Products And Raw materials
Raw materials
Preparation Products
Ryanodine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7854 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Biyu Biotechnology (Shanghai) Co., ltd | 021-26018599 | China | 270 | 56 |