LY 171883
- CAS No.
- 88107-10-2
- Chemical Name:
- LY 171883
- Synonyms
- S-1414;LY 171883;LY-171,833;TOMELUKAST;LY 171883 ISO 9001：2015 REACH;5-[4-4-ACETYL-3-HYDROXY-2-PROPYLPHENOXYBUTYL]-1H-TETRAZOLE;5-[4-(1-ACETYL-2-HYDROXY-3-PROPYLPHENOXY)BUTYL]-1H-TETRAZOLE;2’-hydroxy-3’-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)-acetophenon;1-(2-hydroxy-3-propyl-4-(4-(1h-tetrazol-5-yl)butoxy)phenyl)-ethanon;1-[2-HYDROXY-3-PROPYL-4-[4-(1H-TETRAZOL-5-YL)BUTOXY]PHENYL]ETHANONE
- CBNumber:
- CB1666122
- Molecular Formula:
- C16H22N4O3
- Molecular Weight:
- 318.37
- MDL Number:
- MFCD00211057
- MOL File:
- 88107-10-2.mol
- MSDS File:
- SDS
| Melting point | 117-119℃ |
|---|---|
| Boiling point | 553.0±60.0 °C(Predicted) |
| Density | 1.220±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), |
| form | White solid. |
| pka | 5.02±0.10(Predicted) |
| color | White |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| CAS DataBase Reference | 88107-10-2 |
| FDA UNII | 59762X5CLS |
LY 171883 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67028 | LY 171883, 98% | 88107-10-2 | 10mg | $165 | 2023-06-20 | Buy |
| Cayman Chemical | 70710 | LY171883 ≥98% | 88107-10-2 | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 70710 | LY171883 ≥98% | 88107-10-2 | 10mg | $76 | 2024-03-01 | Buy |
| Cayman Chemical | 70710 | LY171883 ≥98% | 88107-10-2 | 50mg | $312 | 2024-03-01 | Buy |
| Cayman Chemical | 70710 | LY171883 ≥98% | 88107-10-2 | 100mg | $545 | 2024-03-01 | Buy |
LY 171883 Chemical Properties,Uses,Production
Description
LY-171883 (88107-10-2) is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 μM).1 It is also an activator of peroxisome proliferator-activated receptors (PPARs).2,3
Uses
LY 171883 is a selective leukotriene D4 antagonist.
Definition
ChEBI: A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti asthmatic activity.
Biological Activity
Selective, orally active leukotriene D 4 (LTD 4 ) antagonist; inhibits binding of [ 3 H]-LTD 4 to guinea pig lung membranes (K i = 0.63 μ M).? Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).
in vitro
in gh(3) cells, ly-171883 was able to reversibly increase the amplitude of ca(2+)-activated k(+) current concentration-dependently with an ec(50) value of 15 μm. moreover, the treatment of ly-171883 to cytosolic face did not affect single channel conductance of large-conductance ca(2+)-activated k(+) channels in excised inside-out patches recorded from gh(3) cells, however, ly-171883 did increase the channel activity. in addition, the ly-171883-stimulated activity of bk(ca) channels was dependent on membrane potential [1].
in vivo
the effect of ly-171883 on the respiratory and cardiovascular changes in endotoxemia was studied in unanesthetized sheep. in group one, ly-171883 at 4 mg/kg was i.v. injected. in group two, escherichia coli endotoxin (1 μg/kg) was infused, and in group three, ly-171883 at 4 mg/kg was administered before and after the same dose of endotoxin. results showed that infusion of ly-171883 in group one did not alter baseline ventilatory and cardiovascular measurements. in group two, a two-phase pulmonary response was found. an early pulmonary hypertension phase with a fall in cardiac index was observed in group three [2].
References
1) Fleisch et al. (1985), LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl)butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist; J. Pharmacol. Exp. Ther., 233 148 2) Foxworthy and Eacho (1991) Effect of the peroxisome proliferator LY171883 on triglyceride accumulation in rats fed a fat-free diet; Biochem. Pharmacol. 42 1487 3) Kliewer et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors; Proc. Natl. Acad. Sci .USA 91 7355
LY 171883 Preparation Products And Raw materials
LY 171883 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3422 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9972 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
View Lastest Price from LY 171883 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-01-06 | LY 171883
88107-10-2
|
US $1.80 / KG | 1g | 96%-99% | 1kg/10kg/100kg | Career Henan Chemica Co | |
![1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/44eed71e-8968-4571-88fc-15790cc01ba3.jpg) |
2020-03-16 | 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
88107-10-2
|
US $1.00-0.00 / KG | 1KG | 99% | 20 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- LY 171883
88107-10-2
- US $1.80 / KG
- 96%-99%
- Career Henan Chemica Co
-
- 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
88107-10-2
- US $1.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd