DEXBROMPHENIRAMINE MALEATE
- CAS No.
- 2391-03-9
- Chemical Name:
- DEXBROMPHENIRAMINE MALEATE
- Synonyms
- D03704;Disophrol;Disomer (tn);disomermaleate;DexbroMpheniraMin;Brompheniramine d-;Dexbrompheniraminum;d-brompheniraminemaleate;DEXBROMPHENIRAMINE MALEATE;(S)-BroMpheniraMine Maleate
- CBNumber:
- CB1675360
- Molecular Formula:
- C20H23BrN2O4
- Molecular Weight:
- 435.31
- MDL Number:
- MFCD00072141
- MOL File:
- 2391-03-9.mol
| Melting point | 132-134℃ |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| FDA 21 CFR | 341.12 |
| FDA UNII | BPA9UT29BS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | US4026200 |
| HS Code | 2933399090 |
| Toxicity | guinea pig,LD50,oral,259mg/kg (259mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYEBEHAVIORAL: TREMORBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Chemotherapia. Vol. 3, Pg. 120, 1961. |
DEXBROMPHENIRAMINE MALEATE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB19340 | (S)-Brompheniramine maleate | 2391-03-9 | 10mg | $40 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19340 | (S)-Brompheniramine maleate | 2391-03-9 | 25mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19340 | (S)-Brompheniramine maleate | 2391-03-9 | 50mg | $120 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19340 | (S)-Brompheniramine maleate | 2391-03-9 | 100mg | $190 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB19340 | (S)-Brompheniramine maleate | 2391-03-9 | 250mg | $300 | 2021-12-16 | Buy |
DEXBROMPHENIRAMINE MALEATE Chemical Properties,Uses,Production
Originator
Disomer,White,US,1959
Uses
The S-enantimer of Brompheniramine maleate (B686355) as antihistaminic.
Definition
ChEBI: The maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and co junctivitis.
Manufacturing Process
The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3-
(2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at
room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent
using 5 ml there of per gram of solid. Three subsequent crystallizations from
80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in
dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is
obtained from this salt with diethyl ether and aqueous potassium carbonate;
[α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then
reacted with maleic acid.
brand name
Disomer (Schering).
Therapeutic Function
Antihistaminic
General Description
Like the chlorinederivative, the antihistaminic activity of brompheniramineexists predominantly in the dextro isomer, dexbrompheniraminemaleate (D-isomer), and is of comparable potency.
DEXBROMPHENIRAMINE MALEATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6572 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Wuhan Dahua Pharmaceutical Co., Ltd. | 027-59262863 13277907145 3091977954 | China | 4951 | 58 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973186 4009686088 | 3193328036@qq.com | China | 18352 | 68 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10008 | 58 |