ChemicalBook >> CAS DataBase List >>Pregnenolone

Pregnenolone

CAS No.
145-13-1
Chemical Name:
Pregnenolone
Synonyms
prenenolone;5-pregnen-3B-ol-20-one;3β-Hydroxypregn-5-en-20-one;DELTA5-PREGNEN-3BETA-OL-20-ONE;5-Preg;ZK-5553;-20-one;prenolon;pregnolon;nen-3β-oL
CBNumber:
CB1684326
Molecular Formula:
C21H32O2
Molecular Weight:
316.48
MDL Number:
MFCD00003628
MOL File:
145-13-1.mol
Last updated:2024-03-07 16:58:36

Pregnenolone Properties

Melting point 188-190 °C
alpha 28.5 º (c=1, EtOH)
Boiling point 395.89°C (rough estimate)
Density 1.0382 (rough estimate)
vapor pressure 0-0Pa at 20-25℃
refractive index 1.5344 (estimate)
Flash point 9℃
storage temp. Refrigerator
solubility ethanol: soluble10mg/mL, clear, colorless to faintly yellow
form Powder
pka 15.00±0.70(Predicted)
color White to off-white
Water Solubility 41mg/L(room temperature)
Merck 7733
BRN 2059026
InChIKey ORNBQBCIOKFOEO-QGVNFLHTSA-N
LogP 4.4 at 20℃
CAS DataBase Reference 145-13-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 73R90F7MQ8
NCI Drug Dictionary pregnenolone
NIST Chemistry Reference Pregnenolone(145-13-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P280-P305+P351+P338
Safety Statements  22-24/25
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TU5560700
HS Code  29372900

Pregnenolone price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9129 5-Pregnen-3β-ol-20-one ≥98% 145-13-1 1g $31.62 2024-03-01 Buy
Sigma-Aldrich P-104 Pregnenolone solution 100?μg/mL in acetonitrile, certified reference material, Cerilliant? 145-13-1 1mL $70.7 2024-03-01 Buy
Sigma-Aldrich PHR2564 Pregnenolone Pharmaceutical Secondary Standard; Certified Reference Material 145-13-1 100MG $583 2022-05-15 Buy
Cayman Chemical 19864 Pregnenolone ≥98% 145-13-1 500mg $32 2024-03-01 Buy
Cayman Chemical 19864 Pregnenolone ≥98% 145-13-1 1g $40 2024-03-01 Buy
Product number Packaging Price Buy
P9129 1g $31.62 Buy
P-104 1mL $70.7 Buy
PHR2564 100MG $583 Buy
19864 500mg $32 Buy
19864 1g $40 Buy

Pregnenolone Chemical Properties,Uses,Production

Description

Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a number of physiologically active C21 steroids, including the female sex hormone progesterone and the adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19 steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18 female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.

Description

Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens. Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

Chemical Properties

white to off-white powder

Uses

glucocortcoid, antiinflammatory

Uses

Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A

Definition

ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.

General Description

Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.

in vitro

pregnenolone is the precursor from which almost all of the other steroid hormones are made, including dhea, testosterone, progesterone, the estrogens and cortisol. pregnenolone also operates as a powerful neurosteroid in the brain, which modulates the transmission of messages from neuron to neuron and strongly influencing learning and memory processes [1].

in vivo

the ability of pregnenolone sulfate derivatives (pregs) to modulate the age-induced learning impairment was tested in 16- month-old mice using the step-down type of passive avoidance. decreased step-down latency was observed in the passive avoidance task in 16-month-old mice compared to 3-month-old mice, revealing retention deficits in old mice. pretraining injections of pregs dose-dependently improved the 24 h delay retention performances in this task in old mice [1].

References

[1] vallée m, mayo w, le moal m. role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. brain res brain res rev. 2001 nov;37(1-3):301-12.

58701-45-4
145-13-1
Synthesis of Pregnenolone from 3-tert-Butyldimethylsilyloxy Pregnenolone
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View Lastest Price from Pregnenolone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pregnenolone pictures 2024-03-19 Pregnenolone
145-13-1
US $0.00-0.00 / KG 1KG 99 50000KG/month Shanghai Affida new material science and technology center
Pregnenolone pictures 2024-03-19 Pregnenolone
145-13-1
US $0.00-0.00 / KG 1KG 99% 5000 Wuhan Haorong Biotechnology Co.,Ltd
Pregnenolone pictures 2024-03-19 Pregnenolone
145-13-1
US $90.00 / kilograms 10kilograms 99 10 Hebei Dangtong Import and export Co LTD
  • Pregnenolone pictures
  • Pregnenolone
    145-13-1
  • US $0.00-0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center
  • Pregnenolone pictures
  • Pregnenolone
    145-13-1
  • US $0.00-0.00 / KG
  • 99%
  • Wuhan Haorong Biotechnology Co.,Ltd
  • Pregnenolone pictures
  • Pregnenolone
    145-13-1
  • US $90.00 / kilograms
  • 99
  • Hebei Dangtong Import and export Co LTD
PREGNENOLONE(RG) PREGNENOLONE(3BETA-HYDROXYPREGN-5-EN-20-ONE) Progeserone Pregnenolone 5-Pregnenolone pregnenolone solution,100ppm Pregnenolone 0 Pregnenolone/Pregnenolone acetate 3β-Hydroxy-5-pregnen-20-one, 5-Pregnen-3β-ol-20-one 3β-Hydroxy-5-pregnen-20-one, Pregnenolone ZK-5553 Pregnenolone,99% Pregnenolone3beta-Hydroxy-5-pregnen-20-one Pregnelone PREGNENOLONE(P) DELTA5-PREGNEN-3B-OL-20-ONE DELTA-5-PREGNENE-3B-OL-20-ONE DELTA5-PREGNENOLONE 3BETA-HYDROXY-5-PREGNEN-20-ONE 3BETA-HYDROXYPREGN-5-EN-20-ONE 3b-hydroxy-5-pregnen-20-one 5-pregnenolone 5-PREGNEN-3BETA-OL-20-ONE PREGNENOLONE prenolon pregnolon 1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE (3-beta)-pregn-5-en-20-on 3-beta-hydroxy-pregn-5-en-20-on Pregnenlolone Pregnenolone Micron 3Hydroxy-5-Pregnen-20-one 5-pregnen-3β-ol-20-one 1-[(3S,8S,9S,10R,13S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 3β-hydroxy-pregn-5-ene-20-one 4-(4-methylphenyl)-3,5-diphenyl-1,2,4-triazole 1-[(3S,8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-hydroxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Pregnenolone solution -20-one 5-Preg nen-3β-oL fast-shipping Pregnenolone Pregnenolone> Pregnenolone (3beta-Hydroxypregn-5- Arthenolone Pregn-5-en-20-one, 3-hydroxy-, (3β)- 5-Pregnen-3β-oL High quality Pregnenolone 5-Pregnen-3β-ol-20-one 3β-Hydroxypregn-5-en-20-one prenenolone DELTA5-PREGNEN-3BETA-OL-20-ONE 5-pregnen-3B-ol-20-one 3β-Hydroxy-5-pregnen-20-one (3β)-3-Hydroxypregn-5-en-20-one Pregnenolon : 3beta-Hydroxypregn-5-en-20-on Pregn-5-en-20-one, 3-hydroxy-, (3β)- 145-13-1 145-31-1