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PARECOXIB SODIUM

PARECOXIB SODIUM structure

CAS No.: 198470-85-8

Chemical Name:: PARECOXIB SODIUM

Synonyms: Dynastat;Rayzon;SC 69124A;Parecoxib CRS;parexib sodium;Parecoxib-011-Na;Parecoxib sodium;Parecoxib sodiuM sal;Parecoxib sodiuM salt;Parecoxib Impurity 64

CBNumber:: CB21003464

Molecular Formula:: C19H19N2NaO4S

Molecular Weight:: 394.42

MDL Number:

MOL File:: 198470-85-8.mol

MSDS File:: SDS

Last updated:2024-04-25 13:42:50

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PARECOXIB SODIUM Properties

Melting point	273-275°C
storage temp.	Inert atmosphere,2-8°C
solubility	DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
form	Powder
InChI	InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22);;
InChIKey	OGSQVUBPCQXSGW-UHFFFAOYSA-N
SMILES	CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]
FDA UNII	EB87433V6F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS07
Signal word	Danger
Hazard statements	H225-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

PARECOXIB SODIUM price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29017	Parecoxib (sodium salt)	198470-85-8	10mg	$62	2024-03-01	Buy
Cayman Chemical	29017	Parecoxib (sodium salt)	198470-85-8	25mg	$113	2024-03-01	Buy
Cayman Chemical	29017	Parecoxib (sodium salt)	198470-85-8	50mg	$211	2024-03-01	Buy
Cayman Chemical	29017	Parecoxib (sodium salt)	198470-85-8	100mg	$357	2024-03-01	Buy
TRC	P193275	ParecoxibSodium	198470-85-8	100mg	$995	2021-12-16	Buy

Product number	Packaging	Price	Buy
29017	10mg	$62	Buy
29017	25mg	$113	Buy
29017	50mg	$211	Buy
29017	100mg	$357	Buy
P193275	100mg	$995	Buy

PARECOXIB SODIUM Chemical Properties,Uses,Production

Description

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC₅₀ value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED₅₀ = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED₅₀ = 0.08 mg/kg).

Chemical Properties

White Solid

Uses

Anti-inflammatory, analgesic.

Indications

For the short-term treatment of acute pain and post-operative pain i.e., oral surgery, abdominal hysterectomy, myomectomy, total knee replacement, total hip arthroplasty, laparoscopic cholecystectomy, inguinal hernia repair and other general surgery like diagnostic laparoscopy, gastrectomy, hernioplasty, appendectomy, hemithyroidectomy and splenectomy. Parecoxib Sodium may be used pre-operatively to prevent or reduce post-operative pain and it can reduce opioid requirements when they are used concomitantly.

Application

Parecoxib sodium is a water-soluble sodium salt of the amide prodrug of valdecoxib. Parecoxibundergoes enzymatic hydrolysis in vivo to the active moiety valdecoxib, and is formulated as apowder for solution for parenteral administration. Valdecoxib is a selective inhibitor of the enzymeCOX-2.

Biological Functions

A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Pharmacokinetics

Parecoxib (Dynastat) is a prodrug of valdecoxib. Valdecoxib is an NSAID that exhibits antiinflammatory, analgesic and antipyretic properties in animal models. The mechanism of action is believed to be due to inhibition of prostaglandin synthesis primarily through inhibition of COX-2. At therapeutic plasma concentrations in humans valdecoxib does not inhibit cyclooxygenase-1 (COX-1).

PARECOXIB SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

PARECOXIB SODIUM Suppliers

Global( 395)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	lvan.hui@jsytsw.com	China	80	58
Hangzhou Benoy Chemical Co., Ltd	+8617342059697	sales@benoychem.com	China	315	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	122	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	525	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58

Supplier	Advantage
Chengdu Aslee Biopharmaceuticals, Inc.	58
Alfa Chemistry	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
Hangzhou Benoy Chemical Co., Ltd	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Sigma Audley	58
airuikechemical co., ltd.	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58

View Lastest Price from PARECOXIB SODIUM manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	198470-85-8 198470-85-8	US $100.00-60.00 / kg	100kg	99.99%	100Tons	Hebei Dangtong Import and export Co LTD
2024-04-25	Parecoxib sodiuM 198470-85-8	US $15.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-07	Parecoxib sodium 198470-85-8	US $0.00-0.00 / g	1g	99.9%	20 tons	airuikechemical co., ltd.

198470-85-8
198470-85-8
US $100.00-60.00 / kg
99.99%
Hebei Dangtong Import and export Co LTD

Parecoxib sodiuM
198470-85-8
US $15.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Parecoxib sodium
198470-85-8
US $0.00-0.00 / g
99.9%
airuikechemical co., ltd.

PARECOXIB SODIUM Spectrum

PARECOXIB SODIUM(198470-85-8)¹HNMR

198470-85-8(PARECOXIB SODIUM)Related Search:

N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)isobutyraMide 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-METHYL-3,4-DIPHENYL-4,5-DIHYDROISOXAZOL-5-OL 3-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonaMide

4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 2-Phenylacetophenone Valdecoxib IMpurity B Pantoprazole Sodium Paliperidone Z-Oxime

4-(3-methyl-4-phenylisoxazol-5-yl)benzenesulfonamide ethyl 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonate 5-Methyl-3,4-diphenylisoxazole DeoxyBenzoinOxime Valdecoxib 3'-SulfonaMide IMpurity

Parecoxib Impurity H Parecoxib Valdecoxib

1of4

N-[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL)PHENYLSULFONYL]PROPIONAMIDE, SODIUM SALT Parecoxib sodiuM salt N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanaMide SodiuM Salt Rayzon SC 69124A PropanaMide,N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-, sodiuM salt (1:1) Parecoxib sodiuM cloth Parecoxib sodium N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt Parecoxib Sodium Impurity Parecoxib sodiuM sal Parecoxib sodium （Intermediate in China ONLY） sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)(propionyl)amide Parecoxib-011-Na Parecoxib Impurity 64 PARECOXIB SODIUM USP/EP/BP sodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonysodium ((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl) (propionyl)amidel) (propionyl)amide N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt（Parecoxib Sodium） Dynastat N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide sodium hydride Parecoxib sodium Parecoxib Impurity 22 Sodium Salt Parecoxib CRS parexib sodium Parecoxib Impurity 11 Sodium Salt 198470-85-8 98470-85-8 198470-85-5 10.98470-85-8 C19H17N2NaO4S C19H17N2O4SNa C19H18N2O4SNa Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 198470-85-8