5-Methyl-3,4-diphenylisoxazole
- CAS No.
- 37928-17-9
- Chemical Name:
- 5-Methyl-3,4-diphenylisoxazole
- Synonyms
- 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM iMpurity PR-SM;Parecoxib SodiuM interMediate A;Isoxazole, 5-Methyl-3,4-diphenyl-
- CBNumber:
- CB52604537
- Molecular Formula:
- C16H13NO
- Molecular Weight:
- 235.28
- MDL Number:
- MFCD18449672
- MOL File:
- 37928-17-9.mol
Melting point | 96.0 to 100.0 °C |
---|---|
Boiling point | 340.1±21.0 °C(Predicted) |
Density | 1.108±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | -2.53±0.50(Predicted) |
color | White to Off-White |
InChIKey | ZXIRUKJWLADSJS-UHFFFAOYSA-N |
5-Methyl-3,4-diphenylisoxazole price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | M2830 | 5-Methyl-3,4-diphenylisoxazole >98.0%(GC) | 37928-17-9 | 1g | $36 | 2024-03-01 | Buy |
TCI Chemical | M2830 | 5-Methyl-3,4-diphenylisoxazole >98.0%(GC) | 37928-17-9 | 5g | $91 | 2024-03-01 | Buy |
TRC | M312540 | 5-Methyl-3,4-diphenylisoxazole | 37928-17-9 | 500mg | $75 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0390904 | 5-METHYL-3,4-DIPHENYLISOXAZOLE 95.00% | 37928-17-9 | 5MG | $497.88 | 2021-12-16 | Buy |
AK Scientific | Y0376 | 5-Methyl-3,4-diphenylisoxazole | 37928-17-9 | 25g | $178 | 2021-12-16 | Buy |
5-Methyl-3,4-diphenylisoxazole Chemical Properties,Uses,Production
Uses
5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.
Uses
5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.
Synthesis
In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??£? MS(m/z):236(M+H)+£?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).
5-Methyl-3,4-diphenylisoxazole Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
ZHEJIANG ESTCHEM CO.,LTD | 15957180504 | sales@zjestchem.com | China | 193 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12465 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
View Lastest Price from 5-Methyl-3,4-diphenylisoxazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-29 | 5-Methyl-3,4-diphenylisoxazole
37928-17-9
|
US $100.00-60.00 / Grams | 100Grams | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | ||
2024-08-20 | 5-Methyl-3,4-diphenylisoxazole
37928-17-9
|
US $10.00-7.00 / kg | 1kg | 99.9% | 20ton | Hebei Ganmiao New material Technology Co., LTD | ||
2024-08-15 | 5-Methyl-3,4-diphenylisoxazole
37928-17-9
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
- 5-Methyl-3,4-diphenylisoxazole
37928-17-9
- US $100.00-60.00 / Grams
- 99.99%
- Hebei Dangtong Import and export Co LTD
- 5-Methyl-3,4-diphenylisoxazole
37928-17-9
- US $10.00-7.00 / kg
- 99.9%
- Hebei Ganmiao New material Technology Co., LTD
- 5-Methyl-3,4-diphenylisoxazole
37928-17-9
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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