(2E)-2-(nitromethylidene)-1,3-thiazinane
- CAS No.
- 58842-20-9
- Chemical Name:
- (2E)-2-(nitromethylidene)-1,3-thiazinane
- Synonyms
- SD 35651;nithiazine;(2E)-2-(nitromethylidene)-1,3-thiazinane;tetrahydro-2-(nitromethylene)-2H-1,3-thiazine;2H-1,3-Thiazine, tetrahydro-2-(nitromethylene)-
- CBNumber:
- CB21260803
- Molecular Formula:
- C5H8N2O2S
- Molecular Weight:
- 160.19
- MDL Number:
- MOL File:
- 58842-20-9.mol
| Boiling point | 287.9±40.0 °C(Predicted) |
|---|---|
| Density | 1.387±0.06 g/cm3(Predicted) |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 1.16±0.20(Predicted) |
| color | Off-White to Light Yellow |
| Stability | Light Sensitive |
| FDA UNII | F1T7M9EJMU |
| EPA Substance Registry System | Nithiazine (58842-20-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H332-H335-H302-H319-H312-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| RIDADR | 2588 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
(2E)-2-(nitromethylidene)-1,3-thiazinane Chemical Properties,Uses,Production
Description
Nithiazine and other members of the nitromethylene family were shown at an early stage in their development to be cholinergic agonists (and antagonists) by electrophysiology (6). However, unlike nicotine, they mostly act as partial agonists and are open channel blockers, a property resulting from their partial positive charge.
Uses
Nithiazine is a useful building block and insecticide.
Uses
Nithiazine is used as an active ingredient in fly strips (e.g., QuickStrikes Fly Abatement Strip, Sandoz 9023 fly bait station). The strips are most effective against houseflies (Musca domestica). They can be placed in or around the house, animal housing, recycling facilities, or other facilities where abundant houseflies are a nuisance; however, the manufacturer currently does not support residential uses.
Environmental Fate
Nithiazine is extremely unstable in sunlight due to the nitromethylene chromophore. This group absorbs strongly in water at 365 nm with an extinction coefficient about 40 000M-1 cm-1. Direct irradiation results in a loss of the insecticidal activity and formation of a mixture of more than 40 degradation products. The major products of nithiazine photoreduction and dimerization from irradiation at 360 nm in water are nitrile, nitroso, and oxim derivatives, and dimers. Consequently, nithiazine half-time on foliage is only about 30min. Low photostability is the primary reason that nithiazine is not used as an insecticide for field and other environmental applications. Nithiazine stability in aqueous environments is affected by pH. Its half-time is greater than 3months at pH 7, while it is only 3 h at pH 1.1.
Toxicity evaluation
Nithiazine is an agonist acting at the neural nicotinic acetylcholine receptor – Na+/K+ ionophore in mammals and insects. The nicotinic acetylcholine receptors regulate the flow of Na+ and K+ through the channels in the neural postsynaptic membranes. Opening and closing of the channels by acetylcholine maintains the dynamic ratio of the intracellular to extracellular concentrations of Na+ and K+ needed for the initiation of the signal in the postsynaptic neuron. The structural differences between insect and mammalian receptors determine the high selectivity of nithiazine toxicity to insects.
(2E)-2-(nitromethylidene)-1,3-thiazinane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |