(2E)-2-(nitromethylidene)-1,3-thiazinane

(2E)-2-(nitromethylidene)-1,3-thiazinane Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:nithiazine
CAS:58842-20-9
Purity:99% Package:5KG;1KG
(2E)-2-(nitromethylidene)-1,3-thiazinane Basic information
Product Name:(2E)-2-(nitromethylidene)-1,3-thiazinane
Synonyms:(2E)-2-(nitromethylidene)-1,3-thiazinane;SD 35651;nithiazine;tetrahydro-2-(nitromethylene)-2H-1,3-thiazine;2H-1,3-Thiazine, tetrahydro-2-(nitromethylene)-
CAS:58842-20-9
MF:C5H8N2O2S
MW:160.19
EINECS:
Product Categories:
Mol File:58842-20-9.mol
(2E)-2-(nitromethylidene)-1,3-thiazinane Structure
(2E)-2-(nitromethylidene)-1,3-thiazinane Chemical Properties
Boiling point 287.9±40.0 °C(Predicted)
density 1.387±0.06 g/cm3(Predicted)
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka1.16±0.20(Predicted)
color Off-White to Light Yellow
Stability:Light Sensitive
EPA Substance Registry SystemNithiazine (58842-20-9)
Safety Information
RIDADR 2588
HazardClass 6.1(b)
PackingGroup III
MSDS Information
(2E)-2-(nitromethylidene)-1,3-thiazinane Usage And Synthesis
DescriptionNithiazine and other members of the nitromethylene family were shown at an early stage in their development to be cholinergic agonists (and antagonists) by electrophysiology (6). However, unlike nicotine, they mostly act as partial agonists and are open channel blockers, a property resulting from their partial positive charge.
UsesNithiazine is a useful building block and insecticide.
UsesNithiazine is used as an active ingredient in fly strips (e.g., QuickStrikes Fly Abatement Strip, Sandoz 9023 fly bait station). The strips are most effective against houseflies (Musca domestica). They can be placed in or around the house, animal housing, recycling facilities, or other facilities where abundant houseflies are a nuisance; however, the manufacturer currently does not support residential uses.
Environmental FateNithiazine is extremely unstable in sunlight due to the nitromethylene chromophore. This group absorbs strongly in water at 365 nm with an extinction coefficient about 40 000M-1 cm-1. Direct irradiation results in a loss of the insecticidal activity and formation of a mixture of more than 40 degradation products. The major products of nithiazine photoreduction and dimerization from irradiation at 360 nm in water are nitrile, nitroso, and oxim derivatives, and dimers. Consequently, nithiazine half-time on foliage is only about 30min. Low photostability is the primary reason that nithiazine is not used as an insecticide for field and other environmental applications. Nithiazine stability in aqueous environments is affected by pH. Its half-time is greater than 3months at pH 7, while it is only 3 h at pH 1.1.
Toxicity evaluationNithiazine is an agonist acting at the neural nicotinic acetylcholine receptor – Na+/K+ ionophore in mammals and insects. The nicotinic acetylcholine receptors regulate the flow of Na+ and K+ through the channels in the neural postsynaptic membranes. Opening and closing of the channels by acetylcholine maintains the dynamic ratio of the intracellular to extracellular concentrations of Na+ and K+ needed for the initiation of the signal in the postsynaptic neuron. The structural differences between insect and mammalian receptors determine the high selectivity of nithiazine toxicity to insects.
(2E)-2-(nitromethylidene)-1,3-thiazinane Preparation Products And Raw materials
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