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N(4)-hydroxycytidine

N(4)-hydroxycytidine Structure
N(4)-hydroxycytidine structure
CAS No.
3258-02-4
Chemical Name:
N(4)-hydroxycytidine
Synonyms
EIDD-1931;N-Hydroxycytidine;0/4/58;EIDD-193;Uridine, 4-oxime;Monovir impurity A;EIDD 2801-metabolit;EIDD2801-metabolite;N(4)-hydroxycytidine;EIDD-2801-metabolite
CBNumber:
CB21312265
Molecular Formula:
C9H13N3O6
Molecular Weight:
259.22
MDL Number:
MFCD01675695
MOL File:
3258-02-4.mol
Last updated:2023-06-30 15:45:59
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N(4)-hydroxycytidine Properties

Melting point 169-172 °C(Solv: methanol (67-56-1))
Density 1.93±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 25 mg/ml) or in Water (up to 15 mg/ml with warming).
form solid
pka 8.19±0.20(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
FDA UNII C3D11PV2O4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

N(4)-hydroxycytidine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2872 EIDD-1931 ≥98% (HPLC) 3258-02-4 5MG $94.2 2024-03-01 Buy
Sigma-Aldrich SML2872 EIDD-1931 ≥98% (HPLC) 3258-02-4 25MG $381 2024-03-01 Buy
Cayman Chemical 9002958 EIDD-1931 3258-02-4 1mg $36 2024-03-01 Buy
Cayman Chemical 9002958 EIDD-1931 3258-02-4 5mg $87 2024-03-01 Buy
Cayman Chemical 9002958 EIDD-1931 3258-02-4 10mg $155 2024-03-01 Buy
Product number Packaging Price Buy
SML2872 5MG $94.2 Buy
SML2872 25MG $381 Buy
9002958 1mg $36 Buy
9002958 5mg $87 Buy
9002958 10mg $155 Buy

N(4)-hydroxycytidine Chemical Properties,Uses,Production

Description

EIDD-1931 is a ribonucleoside analog with antiviral activity. It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively). It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells. EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.

Uses

EIDD 1931 is an orally bioavailable broad-spectrum antiviral that inhibits SARS-CoV-2 and other multiple endemic, epidemic and bat coronavirus and has the potential for seasonal and pandemic influenza treatment. A broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses.

Definition

ChEBI: N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as a drug metabolite, a human xenobiotic metabolite, an anticoronaviral agent and an antiviral agent. It is a nucleoside analogue and a ketoxime. It is functionally related to a cytidine.

storage

Store at -20°C

References

1) Janion and Glickman (1980),?N4-hydroxycytidine: a mutagen specific for AT to GC transitions;?Mutat. Res.,?72?43 2) Stuyver?et al.?(2003),?Ribonucleotide analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture; Antimicrob. Agents Chemother.,?47?244 3) Costantini?et al.?(2012),?Antiviral activity of nucleoside analogues against norovirus; Antivir. Ther.,?17?981 4) Reynard?et al.?(2015),?Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication; Viruses,?7?6233 5) Ehteshami?et al.?(2017),?Characterization of ?-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus; Antimicrob. Agents Chemother.,?61?e02395-16 6) Yoon?et al.?(2018),?Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses; Antimicrob. Agents Chemother.,?62?e00766-18 7) Barnard?et al.?(2004),?Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine; Antivir. Chem. Chemother., 15 15 8) Pyrc et al. (2006),?Inhibition of human coronavirus NL63 infection at early stages of the replication cycle; Antimicrob. Agents Chemother.,?50?2000 9) Toots et al. (2019),?Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia; Sci. Transl. Med.,?11?eaax5866

N(4)-hydroxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

N(4)-hydroxycytidine Suppliers

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12527 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 10026 58
Shanghai Biolang Biotechnology Co., Ltd. 		+86-15970428662 +86-13397199602 Niky@biolang.cn China 518 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
NewCan Biotech Limited 		58
Shanghai Biolang Biotechnology Co., Ltd. 		58
sgtlifesciences pvt ltd 		58
InvivoChem 		58

View Lastest Price from N(4)-hydroxycytidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N(4)-hydroxycytidine pictures 2022-02-23 N(4)-hydroxycytidine
3258-02-4
 US $9.90-8.80 / g 10g 99.99%HPLC.USP42 1000kgs Shanghai Biolang Biotechnology Co., Ltd.
  • N(4)-hydroxycytidine pictures
  • N(4)-hydroxycytidine
    3258-02-4
  • US $9.90-8.80 / g
  • 99.99%HPLC.USP42
  • Shanghai Biolang Biotechnology Co., Ltd.

3258-02-4(N(4)-hydroxycytidine)Related Search:

Molnupiravir PF-01367338 RESINIFERATOXIN N-Eicosanoyl Serotonin Imiquimod
((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate Uridine, 5'-(2-methylpropanoate) (9CI) Cytidine, 2',3'-O-(1-methylethylidene)-, 5'-(2-methylpropanoate) ((3aR,4R,6R,6aR)-6-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)-
2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) 6-HYDROXYLAMINOURACIL 2',3'-O-isopropylidene cytidine 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one Molnupiravir Impurity 5

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N(4)-hydroxycytidine 1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one 3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one β-D-N4-Hydroxycytidine Beta-d-N4-hydroxycytidine Beta-d-N4-hydroxycytidine (NHC) Uridine, 4-oxime EIDD2801 ,β-D-N4-hydroxycytidine EIDD-193 Molnupiravir Impurity 1 Molnupiravir Impurity A/N-hydroxycytidine 0/4/58 EIDD-1931 (Beta-d-N4-hydroxycytidine 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-oneQ: What is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the CAS Number of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the storage condition of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one N-Hydroxycytidine (EIDD-1931) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg EIDD-1931 N-Hydroxycytidine Chikungunya,equine,Enterovirus,HEV,EIDD 1931,HRV,Hepatitis C virus,Inhibitor,EIDD1931,CHIKV,Topoisomerase,Enterovirus,VEEV,HEVs,NHC,Rhinovirus,HCV,encephalitis,SARS-CoV,EIDD-1931,inhibit,venezuelan,HRVs,SARS coronavirus 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-4-(Hydroxyamino)Pyrimidin-2-One 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one (Molnupiravir Impurity) Monovir impurity A N4-Hydroxycytidine (NHC) EIDD 2801-metabolit EIDD-2801-metabolite EIDD2801-metabolite 3258-02-4 328-02-4