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DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite structure

CAS No.: 199593-09-4

Chemical Name:: DMT-2′O-Methyl-rC(ac) Phosphoramidite

Synonyms: (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite;2'-OMe-N-Ac Cytidine?Amidite

CBNumber:: CB21871625

Molecular Formula:: C42H52N5O9P

Molecular Weight:: 801.86

MDL Number:: MFCD12912403

MOL File:: 199593-09-4.mol

Last updated:2023-05-18 11:31:15

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Properties

Melting point	102 - 104°C
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
pka	10.18±0.20(Predicted)
color	white to off-white
InChIKey	WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,39,42,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
WGK Germany	3
HS Code	29349990

DMT-2′O-Methyl-rC(ac) Phosphoramidite price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C213180	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for PerkinElmer, configured for Polygen	199593-09-4	1G	$125	2024-03-01	Buy
Sigma-Aldrich	C213100	DMT-2′O-Methyl-rC(ac) Phosphoramidite ≥99% (31P-NMR)	199593-09-4	100g	$6540	2024-03-01	Buy
Sigma-Aldrich	C213100	DMT-2′O-Methyl-rC(ac) Phosphoramidite ≥99% (31P-NMR)	199593-09-4	500g	$32550	2024-03-01	Buy
Sigma-Aldrich	C213180	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for PerkinElmer, configured for Polygen	199593-09-4	0.5g	$92.7	2024-03-01	Buy
Sigma-Aldrich	C213130	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for ABI	199593-09-4	1g	$84.7	2024-03-01	Buy

Product number	Packaging	Price	Buy
C213180	1G	$125	Buy
C213100	100g	$6540	Buy
C213100	500g	$32550	Buy
C213180	0.5g	$92.7	Buy
C213130	1g	$84.7	Buy

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Uses,Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

Global( 149)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
Hefei Huana Biomedical Technology Co.,Ltd.	+86-15900695956	shiqin.he@huanaok.com.cn	China	96	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15933	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58

Supplier	Advantage
Wuhu Nuowei chemistry Co., Ltd.	58
Hefei Huana Biomedical Technology Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Yunbio Tech Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from DMT-2′O-Methyl-rC(ac) Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-03-22	2'-OMe-Ac-C CE Phosphoramidite 199593-09-4	US $100.00 / kg	0.009999999776482582kg	99%	5tons	SHANGHAI NOVRIBO BIOTECH
2023-03-14	N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4	US $0.00 / mg	100mg	≥98%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2022-09-24	N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 199593-09-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2'-OMe-Ac-C CE Phosphoramidite
199593-09-4
US $100.00 / kg
99%
SHANGHAI NOVRIBO BIOTECH

N4-Ac-5'-O-DMT-2'-OMe-C-CE
199593-09-4
US $0.00 / mg
≥98%
Hefei Huana Biomedical Technology Co.,Ltd.

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
199593-09-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

199593-09-4(DMT-2′O-Methyl-rC(ac) Phosphoramidite)Related Search:

DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite

Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE DMT-dG(dmf) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite

Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetylacetone Acetylferrocene tributyl acetocitrate

Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

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2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite -5-(4-Acetamido-2-oxopyrimidin-1(2H) 2'-OMe-Ac-C Phosphoramidite 2’-O-Methyl-rC(N-Ac)Phosphoramidite 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite Ac-2'-Ome-rC Phosphoramidite 2'-OMe-Ac-rC -CE Phosphoramidite N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite 2'-OMe-Ac-C Phosphoramidite (~90%) Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 2'-OMe-C(Ac) Phosphoramidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite DMT-2-O-ME-C-CE Phosphoramidite "DMT-2'-O-Me-dC(Ac) Phosphoramidite" N4-Ac-5'-O-DMT-2'-OMe-C-CE DMT-2’-OMe-C(Ac)-CE Phosphoramidite 2'-OMe-N-Ac Cytidine?Amidite Cytidine Impurity 14 DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite 2’-OMe -dC(Ac) Amidite 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA 2'-OMe-Ac-C Phosphoramidite DMT-2'-O-Me-C(Ac)-CE Phosphoramidite N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4 C42H52N5O9P Amidite