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ChemicalBook >> CAS DataBase List >>N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Structure
N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide structure
CAS No.
313480-47-6
Chemical Name:
N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
Synonyms
N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide;Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-;N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide;NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor
CBNumber:
CB21893317
Molecular Formula:
C22H18N2OS
Molecular Weight:
358.46
MDL Number:
MFCD01196557
MOL File:
313480-47-6.mol
Last updated:2023-05-21 10:59:17
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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Properties

storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (697.43 mM; Need ultrasonic)

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Chemical Properties,Uses,Production

Biological Activity

IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1]. IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1].

References

[1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921.

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Suppliers

Global( 21)Suppliers
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InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 991 55
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InvivoChem 		58
TargetMol Chemicals Inc. 		58
Shanghaizehan biopharma technology co., Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58
Shandong Jirun Biomedical Technology Co., Ltd. 58
Bide Pharmatech Ltd. 58
InvivoChem 58
N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Benzenepropanamide, N-2-benzothiazolyl-β-phenyl- N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor 313480-47-6