| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:IGS-1.76
CAS:313480-47-6
Purity:98% HPLC LCMS Package:100mg;500mg;1g
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| | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Basic information |
| Product Name: | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide | | Synonyms: | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide;Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-;N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide;NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor | | CAS: | 313480-47-6 | | MF: | C22H18N2OS | | MW: | 358.46 | | EINECS: | | | Product Categories: | | | Mol File: | 313480-47-6.mol |  |
| | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (697.43 mM; Need ultrasonic) |
| | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Usage And Synthesis |
| Biological Activity | IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1].
IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1]. | | References | [1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921. |
| | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Preparation Products And Raw materials |
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