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NVP-BEP800

NVP-BEP800 structure

CAS No.: 847559-80-2

Chemical Name:: NVP-BEP800

Synonyms: CS-1973;VER82576;VER-82576;NVP-BEP800;NVP-BEP800 BEP-800;NVP-BEP800 USP/EP/BP;VER-82576 (NVP-BEP800);VER-82576;NVP BEP800;VER82576;2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-;2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide

CBNumber:: CB22506238

Molecular Formula:: C21H23Cl2N5O2S

Molecular Weight:: 480.41

MDL Number:: MFCD18251568

MOL File:: 847559-80-2.mol

Last updated:2023-05-21 10:59:17

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NVP-BEP800 Properties

Density	1.396
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic
form	Powder
pka	13.25±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338

NVP-BEP800 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18383	NVP-BEP800 ≥98%	847559-80-2	500μg	$44	2024-03-01	Buy
Cayman Chemical	18383	NVP-BEP800 ≥98%	847559-80-2	1mg	$78	2024-03-01	Buy
Cayman Chemical	18383	NVP-BEP800 ≥98%	847559-80-2	5mg	$193	2024-03-01	Buy
Cayman Chemical	18383	NVP-BEP800 ≥98%	847559-80-2	10mg	$281	2024-03-01	Buy
Usbiological	461049	NVP-BEP 800	847559-80-2	1mg	$333	2021-12-16	Buy

Product number	Packaging	Price	Buy
18383	500μg	$44	Buy
18383	1mg	$78	Buy
18383	5mg	$193	Buy
18383	10mg	$281	Buy
461049	1mg	$333	Buy

NVP-BEP800 Chemical Properties,Uses,Production

Uses

NVP-BEP 800 is a Hsp90 inhibitor which ehibits anti-proliferative effects against cancer cell lines with high expression level of Hsp90.

Biological Activity

nvp-bep800 is a fully synthetic, orally bioavailable inhibitor of hsp90 with ic50 value of 58nm [1].nvp-bep800 binds to the n-terminal atp-binding pocket of hsp90. in a competitive binding fluorescence polarization assay, nvp-bep800 inhibits hsp90β with ic50 value of 58nm. and to other 20 protein kinases, nvp-bep800 shows a ic50 of >10μm. in bt-474 cells and a375 cells, nvp-bep800 causes the hsp90-p23 dissociation and client protein degradation (erbb2) as well as the reduction of client protein phosphorylation (phospho-akt). degradation of these oncogenic client proteins results in tumor cell growth arrest and death. nvp-bep800 inhibits proliferation of tumor cells with an average gi50 of 245nm. and in 46 primary human tumors including small cell lung, mammary cancer and melanoma, the mean ic50 is 750nm. additionally, treatment of nvp-bep800 induces apoptosis in human breast cancer cell lines. the antitumor efficacy of nvp-bep800 is also observed with a dose of 15 or 30 mg/kg/d in a375 xenograft-bearing mice as well as in bt-474 breast cancer xenografts [1].

target

Hsp90β

References

[1] massey aj, schoepfer j, brough pa, brueggen j, chène p, drysdale mj, pfaar u, radimerski t, ruetz s, schweitzer a, wood m, garcia-echeverria c, jensen mr. preclinical antitumor activity of the orally available heat shock protein 90 inhibitor nvp-bep800. mol cancer ther. 2010 apr;9(4):906-19.

NVP-BEP800 Preparation Products And Raw materials

Raw materials

Preparation Products

NVP-BEP800 Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hunan Jibang Biological Technology Co., LTD	+8613776644403	sales02@kingboomtech.com	China	1806	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58
InvivoChem	58
Hunan Jibang Biological Technology Co., LTD	58

View Lastest Price from NVP-BEP800 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	NVP-BEP800 847559-80-2	US $2.00 / KG	1KG	99%	customise	Career Henan Chemical Co

NVP-BEP800
847559-80-2
US $2.00 / KG
99%
Career Henan Chemical Co

NVP-BEP800 Spectrum

NVP-BEP800(847559-80-2)¹HNMR

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NVP-BEP800 2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide VER82576 VER-82576 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide NVP-BEP 800 NVP-BEP 800 2-Amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 2-Amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6- NVP-BEP800 USP/EP/BP VER-82576;NVP BEP800;VER82576 VER-82576 (NVP-BEP800) CS-1973 NVP-BEP800 BEP-800 Thieno[2,3-d]pyrimidine-6-carboxamide, 2-amino-4-[2,4-dichloro-5-[2-(1-pyrrolidinyl)ethoxy]phenyl]-N-ethyl- 847559-80-2 C21H23Cl2N5O2S Inhibitor apis Inhibitors