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TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) structure

CAS No.: 761437-28-9

Chemical Name:: TAE226 (NVP-TAE226)

Synonyms: TAE226;CS-1694;NVP-TAE 226;TAE-226, >98%;TAE226 (NVP-TAE226);TAE226 (NVP-TAE226), >98%;TAE226 (NVP-TAE226) USP/EP/BP;TAE226; TAE-226;TAE 226;NVPTAE226;2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

CBNumber:: CB32589634

Molecular Formula:: C23H25ClN6O3

Molecular Weight:: 468.94

MDL Number:: MFCD12031516

MOL File:: 761437-28-9.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:20

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TAE226 (NVP-TAE226) Properties

Density	1.349
storage temp.	Store at -20°C
solubility	≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
pka	14.57±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

TAE226 (NVP-TAE226) price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17685	NVP-TAE226 ≥98%	761437-28-9	1mg	$44	2024-03-01	Buy
Cayman Chemical	17685	NVP-TAE226 ≥98%	761437-28-9	5mg	$193	2024-03-01	Buy
Cayman Chemical	17685	NVP-TAE226 ≥98%	761437-28-9	10mg	$321	2024-03-01	Buy
Cayman Chemical	17685	NVP-TAE226 ≥98%	761437-28-9	25mg	$692	2024-03-01	Buy
TRC	N925910	NVP-TAE226	761437-28-9	5mg	$255	2021-12-16	Buy

Product number	Packaging	Price	Buy
17685	1mg	$44	Buy
17685	5mg	$193	Buy
17685	10mg	$321	Buy
17685	25mg	$692	Buy
N925910	5mg	$255	Buy

TAE226 (NVP-TAE226) Chemical Properties,Uses,Production

Description

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC₅₀ = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC₅₀ = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC₅₀ = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.

Uses

NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.

Definition

ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.

target

PYK2

References

[1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302.

TAE226 (NVP-TAE226) Preparation Products And Raw materials

Raw materials

Preparation Products

TAE226 (NVP-TAE226) Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Aladdin Scientific	58

View Lastest Price from TAE226 (NVP-TAE226) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-06	TAE226 (NVP-TAE226) 761437-28-9	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

TAE226 (NVP-TAE226)
761437-28-9
US $1.00 / KG
98%
Career Henan Chemical Co

TAE226 (NVP-TAE226) Spectrum

TAE226 (NVP-TAE226)(761437-28-9)¹HNMR

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NVP-TAE 226 TAE226 TAE226 (NVP-TAE226) 2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl- NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide TAE226 (NVP-TAE226) USP/EP/BP CS-1694 TAE226; TAE-226;TAE 226;NVPTAE226 TAE-226, >98% TAE226 (NVP-TAE226), >98% 761437-28-9 Inhibitors