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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid structure

CAS No.: 1335316-40-9

Chemical Name:: (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid

Synonyms: PLV-09-40;Velpatasvir Impurity 6;Velpatasvir Intermediate 5;(2S,5S)-1-(2-Methoxycarbonylamino-;(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline;(5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline;(2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl);L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)-;(5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline;(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic

CBNumber:: CB22750330

Molecular Formula:: C13H22N2O5

Molecular Weight:: 286.32

MDL Number:: MFCD29917577

MOL File:: 1335316-40-9.mol

MSDS File:: SDS

Last updated:2024-04-24 17:21:39

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(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Properties

Melting point	134 - 136°C
Boiling point	489.9±40.0 °C(Predicted)
Density	1.198±0.06 g/cm3(Predicted)
storage temp.	-20°C, Inert atmosphere
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.61±0.40(Predicted)
color	Off-White to Pale Beige
InChI	InChI=1S/C13H22N2O5/c1-7(2)10(14-13(19)20-4)11(16)15-8(3)5-6-9(15)12(17)18/h7-10H,5-6H2,1-4H3,(H,14,19)(H,17,18)/t8-,9-,10-/m0/s1
InChIKey	PNAXKGVRCAXIJK-GUBZILKMSA-N
SMILES	C(O)(=O)[C@@H]1CC[C@H](C)N1C(=O)[C@H](C(C)C)NC(OC)=O

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M261343	(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline	1335316-40-9	1g	$55	2021-12-16	Buy
Crysdot	CD22004812	(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid 97%	1335316-40-9	1g	$130	2021-12-16	Buy
Chemenu	CM101923	(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline 97%	1335316-40-9	5g	$224	2021-12-16	Buy
Chemenu	CM101923	(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline 97%	1335316-40-9	10g	$370	2021-12-16	Buy
Crysdot	CD22004812	(2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylicacid 97%	1335316-40-9	5g	$400	2021-12-16	Buy

Product number	Packaging	Price	Buy
M261343	1g	$55	Buy
CD22004812	1g	$130	Buy
CM101923	5g	$224	Buy
CM101923	10g	$370	Buy
CD22004812	5g	$400	Buy

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Uses,Production

Uses

(5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline is an antiviral agent and Velpatasvir (V116000) intermediate. Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Synthesis

To an ice-cold stirred solution of ethyl (2S,5S)-1 -[(2S)-2- (methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidine-2- carboxylate (5.6 g, 17.8 mmol) in ethanol (18 ml) is added a solution of lithium hydroxide monohydrate (17.8 mL of 1.7 M, 30.3 mmol). The reaction mixture is stirred for 5 hours at rt. The reaction mixture is concentrated, diluted with water, washed with ether. The aqueous solution is acidified with aq. 1 N HCl, extracted with CH2CI2. The combined extracts are washed with brine, dried (Na2S04), concentrated to afford (2S,5S)-1 -[(2S)-2-(methoxycarbonylamino)-3- methyl-butanoyl]-5-methyl-pyrrolidine-2-carboxylic acid (5g, 94%) as a white solid.

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Suppliers

Global( 173)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Famo Biotech Co Ltd	+86-36680037 +86-18550473860	mayan@famobiotech.com;sales@famobiotech.com	China	503	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	283	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58

Supplier	Advantage
Shanghai Famo Biotech Co Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hangzhou Cyanochem Co., Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-08	(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9	US $50.00 / kg	1kg	99%	10000tons	Anhui Ruihan Technology Co., Ltd
2023-04-12	(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9	US $18.00 / Kg/Bag	1Kg/Bag	Above 99.95%	Weekly supply of 1000 Kg	Wuhan Dujiang Industrial Co., Ltd.
2022-09-27	(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
1335316-40-9
US $50.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
1335316-40-9
US $18.00 / Kg/Bag
Above 99.95%
Wuhan Dujiang Industrial Co., Ltd.

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid
1335316-40-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

1335316-40-9((2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid)Related Search:

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) 9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one Aprepitant (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid

N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir Velpatasvir intermediate Velpatasvir intermediate

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1of4

(2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid (2S,4S)-1-((R)-2-((methoxycarbonyl) amino)-2-phenylacetyl)-4-(methoxy methyl)pyrrolidine-2-carboxylic acid (5S)-N-(Methoxycarbonyl)-L-valyl-5-methyl-L-proline (2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 3. (2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3- methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid (2S,5S)-1-((S)-2-(methoxycarbonyl)-3-methylbutanoyl) (2S,5S)-1-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-methyl-pyrrolidine-2-carboxylic acid N-[2-(S)-[(Methoxycarbonyl)amino]-3-methylbutyryl]-(5S)-5-Methyl-L-proline (2S,5S)-1-((S)-2-METHOXYCARBONYLAMINO)-3-METHYLBUTYRYL)-5-METHYLPYRROLIDINE-2-CARBOXYLIC ACID (2S,5S)-1-(2-Methoxycarbonylamino- Velpatasvir Intermediate 5 Velpatasvir Impurity 6 (5 S)-N-(methoxyl)- L- valanyl-5-methyl- L- proline L-Proline, N-(methoxycarbonyl)-L-valyl-5-methyl-, (5S)- (5S)-N-(methoxycarbonyl) -L-valaminoyl-5-methyl-L-proline (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic PLV-09-40 (2R,5R)-1-((S)-2-(Methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 1335316-40-9 1416134-40-9