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Velpatasvir

Velpatasvir structure

CAS No.: 1377049-84-7

Chemical Name:: Velpatasvir

Synonyms: GS 5816;CS-2204;Vipatavir;Vipataivir;Velpatasvir;MFCD28411371;GS 5816;GS-5816;Velpatasvir API;Velpatasvir(PVP);Unifiram (DM-232)

CBNumber:: CB62743053

Molecular Formula:: C49H54N8O8

Molecular Weight:: 883

MDL Number:: MFCD28411371

MOL File:: 1377049-84-7.mol

Last updated:2023-09-20 16:43:00

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Velpatasvir Properties

Melting point	>170oC (dec.)
Density	1.314±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (>25 mg/ml)
form	solid
pka	10.75±0.46(Predicted)
color	Pale yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII	KCU0C7RS7Z
NCI Drug Dictionary	velpatasvir

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H413

NFPA 704

	0
2		0

Velpatasvir price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21280	Velpatasvir ≥98%	1377049-84-7	10mg	$32	2024-03-01	Buy
Cayman Chemical	21280	Velpatasvir ≥98%	1377049-84-7	50mg	$86	2024-03-01	Buy
Cayman Chemical	21280	Velpatasvir ≥98%	1377049-84-7	100mg	$139	2024-03-01	Buy
Cayman Chemical	21280	Velpatasvir ≥98%	1377049-84-7	250mg	$298	2024-03-01	Buy
TRC	V116000	Velpatasvir	1377049-84-7	500mg	$470	2021-12-16	Buy

Product number	Packaging	Price	Buy
21280	10mg	$32	Buy
21280	50mg	$86	Buy
21280	100mg	$139	Buy
21280	250mg	$298	Buy
V116000	500mg	$470	Buy

Velpatasvir Chemical Properties,Uses,Production

Description

Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2

Uses

Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Definition

ChEBI: A complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes.

References

Link et al. (2019), Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi? and Epclusa?; Bioorg. Med. Chem. Lett., 29 2415 Kadioglu et al. (2020), Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning; Comput. Biol. Med. 133 104359

Velpatasvir synthesis

Synthesis of Velpatasvir from Velpatasvir-A12

Velpatasvir Preparation Products And Raw materials

Raw materials

Preparation Products

Velpatasvir Suppliers

Global( 268)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Chenghui-Shuangda Chemical Co.,Ltd	+86-531-58897082	ericqiao@jnchsd.com	CHINA	158	58
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
shandong perfect biotechnology co.ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Chenghui-Shuangda Chemical Co.,Ltd	58
TianYuan Pharmaceutical CO.,LTD	58

View Lastest Price from Velpatasvir manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-12	Velpatasvir(PVP) 1377049-84-7	US $0.00 / g	1g	98% HPLC	100kg	shandong perfect biotechnology co.ltd
2023-11-27	Velpatasvir 1377049-84-7	US $0.00-0.00 / mg	5mg	99%	50kg	Wuhan Senwayer Century Chemical Co.,Ltd
2023-11-27	Velpatasvir 1377049-84-7	US $0.00-0.00 / mg	5mg	99%	50kg	Wuhan Senwayer Century Chemical Co.,Ltd

Velpatasvir(PVP)
1377049-84-7
US $0.00 / g
98% HPLC
shandong perfect biotechnology co.ltd

Velpatasvir
1377049-84-7
US $0.00-0.00 / mg
99%
Wuhan Senwayer Century Chemical Co.,Ltd

Velpatasvir
1377049-84-7
US $0.00-0.00 / mg
99%
Wuhan Senwayer Century Chemical Co.,Ltd

Velpatasvir Spectrum

Velpatasvir(1377049-84-7)¹HNMR

1377049-84-7(Velpatasvir)Related Search:

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Velpatasvir intermediate Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone

Velpatasvir intermediate (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid BOC-L-PYROGLUTAMIC ACID BENZYL ESTER

1of4

Velpatasvir velpatasvir(GS-5816) methyl ((2s)-1-((2s,5s)-2-(9-(2-((2s,4s)-1-((2r)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1h-imidazol-5-yl)-1,11-dihydroisochromeno(4',3':6,7)naphtho(1,2-d)imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate Velpatasvir API Unifiram (DM-232) Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-y MFCD28411371 Product:Velpatasvir Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo- GS 5816;GS-5816 CS-2204 Velpatasvir (Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[4-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H- imidazol-2-yl]-4-(methoxymethyl)-1-pyrrol Velpatasvir intermediate A13 Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester Velpatasvir (10mM in DMSO) GS-5816(Velpatasvir) TIANFU CHEM Velpatasvir GS 5816 Velpatasvir(PVP) Velpatasvir inteVelpatasvir intermediate A13rmediate A13 Vipataivir N-(1R)-2-(2S,4S)-2-5-1,11-Dihydro-2-(2S,5S)-1-(2S)-2-(methoxycarbonyl)amino-3-methyl-1-oxo-butyl-5-methylpyrrolidin-2-yl2benzopyrano4',3':6,7naphtho1,2-dimidazol-9-yl-1H-imidazol-2-yl-4-(methoxymethyl)-pyrrolidin-1-yl-2-oxo-1-phenylethylcarbamic acid methyl ester Vipatavir Methyl ((2S)-1-((2S,5S)-2-(9-(2-((2S,4S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 1377049-84-7 377049-84-7 C49H54N8O8 1377049-84-7