Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Structure
2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol structure
CAS No.
1204975-42-7
Chemical Name:
2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol
Synonyms
LEQ-506;NVP-LEQ506;LEQ-506,Inhibitor,LEQ 506,Smo,LEQ506,Smoothened,inhibit;(R)-2-(5-(4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol;2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol;2-Pyrazinemethanol, 5-[(2R)-4-[4,5-dimethyl-6-(phenylmethyl)-3-pyridazinyl]-2-methyl-1-piperazinyl]-α,α-dimethyl-;2-[(R)-4-(6-benzyl-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-yl]-propan-2-ol
CBNumber:
CB23138265
Molecular Formula:
C25H32N6O
Molecular Weight:
432.56
MDL Number:
MFCD27987902
MOL File:
1204975-42-7.mol
MSDS File:
SDS
Last updated:2023-09-04 15:50:00
Request For Quotation

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Properties

Boiling point 685.4±55.0 °C(Predicted)
Density 1.170±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 100 mg/mL (231.18 mM)
pka 12.84±0.29(Predicted)
FDA UNII 6SJX1T5HJD

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0011636 LEQ506 98.27% 1204975-42-7 1mg $751 2021-12-16 Buy
ChemScene CS-0011636 LEQ506 98.27% 1204975-42-7 5mg $1202 2021-12-16 Buy
ChemScene CS-0011636 LEQ506 98.27% 1204975-42-7 10mg $1923 2021-12-16 Buy
Crysdot CD11332423 LEQ506 95% 1204975-42-7 250mg $1150 2021-12-16 Buy
Crysdot CD11332423 LEQ506 95% 1204975-42-7 50mg $450 2021-12-16 Buy
Product number Packaging Price Buy
CS-0011636 1mg $751 Buy
CS-0011636 5mg $1202 Buy
CS-0011636 10mg $1923 Buy
CD11332423 250mg $1150 Buy
CD11332423 50mg $450 Buy

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Chemical Properties,Uses,Production

Uses

LEQ506, is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29796 68
Nanjing KaiMubo Pharmaceutical Co., Ltd. 025-66162170 China 7183 55
Nanjing Qishi Biotechnology Co. Ltd. 19822610310 3122922726@qq.com China 1346 58
Nanjing Asfam Pharmaceutical Technology Co., Ltd. 025-58867862 18751812725 sales@ace-pharm.com China 1997 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
BOC Sciences 65
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Nanjing KaiMubo Pharmaceutical Co., Ltd. 55
Nanjing Qishi Biotechnology Co. Ltd. 58
Nanjing Asfam Pharmaceutical Technology Co., Ltd. 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol Spectrum

2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol(1204975-42-7)1HNMR
2-[4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5-yl]-propan-2-ol 2-[(R)-4-(6-benzyl-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-yl]-propan-2-ol NVP-LEQ506 LEQ-506 (R)-2-(5-(4-(6-Benzyl-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)propan-2-ol 2-Pyrazinemethanol, 5-[(2R)-4-[4,5-dimethyl-6-(phenylmethyl)-3-pyridazinyl]-2-methyl-1-piperazinyl]-α,α-dimethyl- LEQ-506,Inhibitor,LEQ 506,Smo,LEQ506,Smoothened,inhibit 1204975-42-7