Galantamine-d3 (hydrobromide)
- CAS No.
- 2140262-53-7
- Chemical Name:
- Galantamine-d3 (hydrobromide)
- Synonyms
- Galantamine-d3 (hydrobromide);(4aS,6R,8aS)-3-(methoxy-d3)-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol,monohydrobromide
- CBNumber:
- CB24814582
- Molecular Formula:
- C17H22BrNO3
- Molecular Weight:
- 368.27
- MDL Number:
- MOL File:
- 2140262-53-7.mol
Galantamine-d3 (hydrobromide) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26103 | Galantamine-d3 (hydrobromide) | 2140262-53-7 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 26103 | Galantamine-d3 (hydrobromide) | 2140262-53-7 | 1mg | $230 | 2024-03-01 | Buy |
| AK Scientific | 1947EG | (1S,12S,14R)-4-Methyl-9-(trideuteriomethoxy)-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide | 2140262-53-7 | 1mg | $353 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D33993 | Galantamine-d3 Hydrobromide | 2140262-53-7 | 5mg | $1550 | 2021-12-16 | Buy |
Galantamine-d3 (hydrobromide) Chemical Properties,Uses,Production
Biological Activity
Galantamine-d3 is intended for use as an internal standard for the quantification of galantamine by GC- or LC-MS. Galantamine is an alkaloid originally isolated from the bulbs and flowers of Galanthus that inhibits acetylcholinesterase (AChE; IC50 = 636 nM).1 It reverses growth inhibition and inhibits apoptosis, autophagic flux, and production of reactive oxygen species (ROS) induced by amyloid-β (Aβ) in neuronally differentiated PC12 cells.2 Galantamine prevents soman toxicity and inhibits acetylcholinesterase in cynomolgus macaques (ED50s = 590 and 362 μg/kg, respectively).3 It also decreases escape latency in the Morris water maze and the total hippocampal area of Aβ plaques in an APP/PS1 transgenic mouse model of Alzheimer's disease.4
References
1.Rook, Y., Schmidtke, K.U., Gaube, F., et al.Bivalent β-carbolines as potential multitarget anti-Alzheimer agentsJournal of Medicinal Chemistry53(9)3611-3617(2010) 2.Jiang, S., Zhao, Y., Zhang, T., et al.Galantamine inhibits β-amyloid-induced cytostatic autophagy in PC12 cells through decreasing ROS productionCell Prolif.51(3)e12427(2018) 3.Hamilton, L.R., Schachter, S.C., and Myers, T.M.Time course, behavioral safety, and protective efficacy of centrally active reversible acetylcholinesterase inhibitors in cynomolgus macaquesNeurochem. Res.42(7)1962-1971(2017) 4.Wu, Z., Zhao, L., Chen, X., et al.Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic miceExp. Gerontol.72244-250(2015)
Galantamine-d3 (hydrobromide) Preparation Products And Raw materials
Raw materials
Preparation Products
Galantamine-d3 (hydrobromide) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Supplier | Advantage |
|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |