4-HYDROXYPHENYLRETINAMIDE
- CAS No.
- 65646-68-6
- Chemical Name:
- 4-HYDROXYPHENYLRETINAMIDE
- Synonyms
- hpr;4HPR;MK-4016;RETINAMIDE;CNTFRalpha;FENRETINIDE;Fenretinimide;Fenretinide(4-HPR);Fenretinide, >=98%;p-Hydroxyphenylretinamide
- CBNumber:
- CB2680860
- Molecular Formula:
- C26H33NO2
- Molecular Weight:
- 391.55
- MDL Number:
- MFCD00792674
- MOL File:
- 65646-68-6.mol
- MSDS File:
- SDS
| Melting point | 162-163°C |
|---|---|
| Boiling point | 597.6±42.0 °C(Predicted) |
| Density | 1.081±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Orange solid |
| pka | 9.98±0.26(Predicted) |
| color | Yellow |
| λmax | 362nm(MeOH)(lit.) |
| Merck | 14,3998 |
| Stability | Light Sensitive - Protect from Light Exposure |
| InChIKey | AKJHMTWEGVYYSE-FXILSDISSA-N |
| CAS DataBase Reference | 65646-68-6(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | fenretinide |
| FDA UNII | 187EJ7QEXL |
| NCI Drug Dictionary | fenretinide |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H360 | |||||||||
| Precautionary statements | P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 60-61-20/21/22-36/37/38 | |||||||||
| Safety Statements | 53-26-36/37/39-45-52 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VH6420000 | |||||||||
| HS Code | 2924297099 | |||||||||
| NFPA 704 |
|
4-HYDROXYPHENYLRETINAMIDE price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB1301585 | ANTI-HPR (CENTER) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 65646-68-6 | 400μl | $481 | 2024-03-01 | Buy |
| Sigma-Aldrich | H7779 | Retinoic acid p-hydroxyanilide ≥98% (HPLC), powder | 65646-68-6 | 5mg | $212 | 2024-03-01 | Buy |
| Sigma-Aldrich | 390900 | 4-Hydroxyphenylretinamide A synthetic amide of all- | 65646-68-6 | 5mg | $216 | 2024-03-01 | Buy |
| TCI Chemical | H1464 | all-trans-N-(4-Hydroxyphenyl)retinamide >98.0%(HPLC) | 65646-68-6 | 10mg | $174 | 2024-03-01 | Buy |
| TCI Chemical | H1464 | all-trans-N-(4-Hydroxyphenyl)retinamide >98.0%(HPLC) | 65646-68-6 | 100mg | $693 | 2024-03-01 | Buy |
4-HYDROXYPHENYLRETINAMIDE Chemical Properties,Uses,Production
Chemical Properties
4-HYDROXYPHENYLRETINAMIDE is Yellow Powder
Uses
4-HYDROXYPHENYLRETINAMIDE is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer
Uses
Retinoic acid receptor ligand
Uses
A synthetic analog of Vitamin A.
Definition
ChEBI: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in ivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
General Description
Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.
Biological Activity
Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo . Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Biochem/physiol Actions
Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.
storage
Store at -20°C
References
[1] roberto benelli, stefano monteghirfo, roberta venè, francesca tosettiand nicoletta ferrari.the chemopreventive retinoid 4hpr impairs prostate cancer cell migration and invasion by interfering with fak/akt/gsk3β pathway andβ-catenin stability. molecular cancer.2010, 9:142-154.
[2] anita l. sabichi, denver t. hendricks, mary a. bober, michael j. birrer. retinoic acid receptorβexpression and growthinhibition of gynecologic cancer cells by thesynthetic retinoidn-(4-hydroxyphenyl) retinamide. journal of the national cancer institute. 1998, 90(8): 597-605.
[3] shi-yong sun, ping yue, and reuben lotan. induction of apoptosis by n-(4-hydroxyphenyl)retinamide andits association with reactive oxygen species, nuclearretinoic acid receptors, and apoptosis-related genes in human prostate carcinoma cells.molecular pharmacology. 1999, 55:403–410.
4-HYDROXYPHENYLRETINAMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
View Lastest Price from 4-HYDROXYPHENYLRETINAMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | Fenretinide
65646-68-6
|
US $16.00 / Kg/Bag | 1Kg/Bag | 99% | 3kg | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2019-09-04 | 4-HYDROXYPHENYLRETINAMIDE
65646-68-6
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Fenretinide
65646-68-6
- US $16.00 / Kg/Bag
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- 4-HYDROXYPHENYLRETINAMIDE
65646-68-6
- US $5.00 / KG
- 99%
- Career Henan Chemical Co
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