Thevetiaflavone
- CAS No.
- 29376-68-9
- Chemical Name:
- Thevetiaflavone
- Synonyms
- Thevetiaflavone;5-O-METHYLAPIGENIN;Apigenin 5-methylether;Apigenin 5-O-monomethyl ether;4',7-Dihydroxy-5-methoxyflavone;Flavone,4',7-dihydroxy-5-methoxy- (8CI);Apigenin-5-methyl ether,5-0-Methylapigenin;7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-4H-chromen-4-one;4H-1-Benzopyran-4-one,7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-;ethylprop-2-enoate,2-methylprop-2-enoicacid,propane-1,2-diol,styrene
- CBNumber:
- CB2748959
- Molecular Formula:
- C16H12O5
- Molecular Weight:
- 284.26
- MDL Number:
- MFCD02683421
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Thevetiaflavone price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Arctom | AS027151 | Thevetiaflavone ≥98% | 29376-68-9 | 5mg | $316 | 2021-12-16 | Buy |
CSNpharm | CSN14606 | Thevetiaflavone | 29376-68-9 | 1mg | $416 | 2021-12-16 | Buy |
Arctom | CFN96124 | Thevetiaflavone ≥98% | 29376-68-9 | 5mg | $513 | 2021-12-16 | Buy |
CSNpharm | CSN14606 | Thevetiaflavone | 29376-68-9 | 5mg | $791 | 2021-12-16 | Buy |
Crysdot | CD32001723 | Thevetiaflavone 95+% | 29376-68-9 | 5mg | $802 | 2021-12-16 | Buy |
Thevetiaflavone Chemical Properties,Uses,Production
Uses
Thevetiaflavone inhibited the secretion of β-glucuronidase from neutrophils in rabbits, ED50 was 20μM. And it inhibited sarcoplasmic reticulum Ca2+-ATPase, when the concentration was 100μM, the inhibition rate was 69 %.
Preparation
The method for obtaining a refined extract from capers, comprising the following steps: a) making the concentrated capers crude extract go up to macroporous adsorption resin chromatography, and eluting with water and ethanol solution; b) eluting with ethanol solution , that is, the refined extract of capers.
Biological Activity
Thevetiaflavone can up-regulate the expression of Bcl-2 and down-regulate the expression of Bax and caspase-3.
in vivo
Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that it decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction , including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. It reduces the intracellular Ca 2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of the vetiaflavone in vivo and its application in the clinic.
Thevetiaflavone Preparation Products And Raw materials
Raw materials
Preparation Products
Thevetiaflavone Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5654 | 65 |
Shanghai Winherb Medical Technology Co., Ltd. | 400-186-5138 13341702378 | winherb@126.com | China | 1009 | 58 |
Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 7059 | 55 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |