Dioscin | 19057-60-4

Dioscin Properties

Melting point	275～277℃
alpha	D13 -115° (c = 0.373 in ethanol)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	12?+-.0.70(Predicted)
form	Solid
color	White to Off-White
EWG's Food Scores	1
FDA UNII	3B95U4OLWV

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements	24/25
HS Code	29389090
Toxicity	mouse,LD50,subcutaneous,> 300mg/kg (300mg/kg),Japanese Kokai Tokyo Koho Patents. Vol. #91-271224,

Dioscin price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11834	Dioscin ≥95%	19057-60-4	10mg	$121	2024-03-01	Buy
Cayman Chemical	11834	Dioscin ≥95%	19057-60-4	25mg	$257	2024-03-01	Buy
Cayman Chemical	11834	Dioscin ≥95%	19057-60-4	50mg	$481	2024-03-01	Buy
Cayman Chemical	11834	Dioscin ≥95%	19057-60-4	100mg	$841	2024-03-01	Buy
TRC	D485230	Dioscin	19057-60-4	2.5g	$1255	2021-12-16	Buy

Product number	Packaging	Price	Buy
11834	10mg	$121	Buy
11834	25mg	$257	Buy
11834	50mg	$481	Buy
11834	100mg	$841	Buy
D485230	2.5g	$1255	Buy

Dioscin Chemical Properties,Uses,Production

Description

Dioscin is extracted from Dioscorea nipponica. Rhizoma Dioscoreae Nipponicae is the dry rhizome of this plant. It can be orally used to treat joint pain, arthritis, malaria, and chronic bronchitis. In addition, it can also be used externally to treat sore carbuncle swollen. Rhizoma Dioscoreae Nipponicae is commonly used in the northeast region, Shanxi province, and Shandong province of China.

Physical properties

Appearance: white powder. Solubility: insoluble in water, petroleum ether, and benzene; soluble in methanol, ethanol, and acetic acid; slightly soluble in acetone and amyl alcohol. Melting point: 294–296℃. Specific optical rotation: ?115° (c?=?0.373, ethanol).

History

Japanese scientists firstly reported and analyzed the structure of dioscin isolated from the saponins of Japanese Dioscoreaceae. V . However, the biological activities of dioscin have not attracted the interests of scientists until the late 1990s and the beginning of this century. It is now believed that dioscin may have therapeutic effects on reducing blood lipids and protecting the liver, as well as antivirus, antiinflammatory, and antitumor effects. After the implementation of standardization of traditional Chinese medicine, dioscin as the quality control specification of Dioscorea nipponica Makino and other traditional Chinese medicine has attracted more attentions and researches. In China, dioscin tablets have been used to treat hyperlipidemia in the clinical practice. However, no corresponding drugs are available on the market in other countries. In addition, dioscin is also an important predecessor for synthesizing steroid hormones . Dioscorea nipponica Makino, which is used to extract dioscin, primarily comes from wild plants, whose resources are limited.

Uses

Dioscin, a natural steroid saponin that has been shown to promote anticancer activity against several forms of cancers. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Uses

Dioscin, a natural steroid saponin that has been shown to promote anticancer activity against several forms of cancers. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Definition

ChEBI: Dioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. It has a role as a metabolite, an antifungal agent, an antiviral agent, an antineoplastic agent, an anti-inflammatory agent, a hepatoprotective agent, an apoptosis inducer and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a spirostanyl glycoside, a spiroketal, a hexacyclic triterpenoid and a trisaccharide derivative. It is functionally related to a diosgenin. It derives from a hydride of a spirostan.

Indications

This drug was recorded in the national standards for chemical drugs, volume 5. Dioscin tablets, containing total dioscin, are used to treat coronary heart disease, coronary insufficiency, as well as control hyperlipidemia.

Pharmacology

Studies showed that compound preparations containing dioscin can increase coronary blood flow, reduce myocardial oxygen consumption, and protect myocardial ischemia and ischemia-reperfusion injury, which is beneficial for alleviating myocardial ischemia and angina. In addition, dioscin can regulate the lipid metabolism and improve hemodynamics. Dioscin can also prevent atherosclerosis by reducing serum total cholesterol, triglyceride, low-density lipoprotein, and oxidized lowdensity lipoprotein, reducing the whole blood viscosity and plasma viscosity at high and low shear rates, and relieving arterial wall lipid infiltration and plaque formation. Furthermore, dioscin can reduce liver fat deposition, which may be related to promoting cholesterol secretion metabolism.
It has also been reported that dioscin can induce the apoptosis of a variety of tumor cells, including gastric cancer cells, breast cancer cells, lung cancer cells, oral squamous cell carcinoma, and cervical cancer cells. The mechanisms are related to reducing the oxidative stress and inhibiting some cellular survival signaling pathways
Dioscin can induce antioxidant enzymes, lower blood lipids, improve insulin resistance, inhibit the inflammatory response, reduce the damage of alcoholic hepatitis, and decrease the hepatic injury induced by acetaminophen .

Dioscin Preparation Products And Raw materials

Raw materials

Preparation Products

Dehydroepiandrosterone

Dioscin Suppliers

Global( 291)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	563	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58
BOC Sciences	58

View Lastest Price from Dioscin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-28	Dioscin 19057-60-4	US $0.00 / mg	20mg	≥98% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2024-04-26	Dioscin 19057-60-4	US $0.00-0.00 / kg	0.10000000149011612kg	≥98%	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-04-23	Dioscin 19057-60-4	US $200.00-85.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd

Dioscin
19057-60-4
US $0.00 / mg
≥98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Dioscin
19057-60-4
US $0.00-0.00 / kg
≥98%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Dioscin
19057-60-4
US $200.00-85.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Dioscin Spectrum

Dioscin(19057-60-4)MS

19057-60-4(Dioscin)Related Search:

Saponin POLYPHYLLIN B (RG) Chonglou Saponin II Matrine Esculin

Icariin POLYPHYLLIN E (RG) Paris saponin V palmitate POLYPHYLLIN D Chonglou Saponin VII

Polyphyllin VI Prosapogenin A 【dioscin】 27-Hydroxycholesterol PROTOGRACELLIN methyl protodioscin

Diosgenin glucoside Diosgenin Protodioscin

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DIOSCIN beta-d-glucopyranoside,(3-beta,25r)-spirost-5-en-3-ylo-6-deoxy-alpha-l-mannop Dioscin(Collettiside III) Dioscin / Diosgenyl 2,4-Di-O-α-L-rhamnopyranosyl-β-D-glucopyranoside collettisideiii dioscine yranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl)-(1-4))- DIOSCIN(P) β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]- (25R)-3β-[2-O,4-O-Bis(α-L-rhamnopyranosyl)-β-D-glucopyranosyloxy]spirosta-5-ene [(25R)-Spirost-5-en-3β-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside [(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-bis(α-L-rhamnopyranosyl)-β-D-glucopyranoside [(25R)-Spirosta-5-ene-3β-yl]2-O,4-O-di-α-L-rhamnopyranosyl-β-D-glucopyranoside beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl o-6-deoxy-alpha-L-mannopyranosyl-(1-2)-o-(6-deoxy-alpha-L-mannopyranosyl-(1-4))- Ccris 4123 Dioscin (6ci,7ci,8ci) Diosgenin bis-alpha-L-rhamnopyranosyl)-(1-2 and 1-4)-beta-D-glucopyranoside DIOSCIN(RG) Dioscin, 98%, from Dioscorea opposita Thunb. Dioscin 19057-60-4 Dioscin Green Plants Extracts 19057-60-4 Dioscorea Nipponica Source COLLETTISIDE III; CCRIS 4123 Yam Extract Dioscin ioscin Dioscin USP/EP/BP Dioscin (CCRIS 4123) Polyphyllin lll (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol) (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol) 19057-60-4 C45H72O16 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Miscellaneous Natural Products Natural Plant Extract The group of Dioscin