ChemicalBook >> CAS DataBase List >>AZ32
AZ32
- CAS No.
- 2288709-96-4
- Chemical Name:
- AZ32
- Synonyms
- AZ32;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
- CBNumber:
- CB28095233
- Molecular Formula:
- C20H16N4O
- Molecular Weight:
- 328.37
- MDL Number:
- MFCD31715431
- MOL File:
- 2288709-96-4.mol
Last updated:2023-09-04 15:51:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
AZ32 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2551 | AZ32 ≥98% (HPLC) | 2288709-96-4 | 5MG | $128 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2551 | AZ32 ≥98% (HPLC) | 2288709-96-4 | 25MG | $494 | 2024-03-01 | Buy |
| Cayman Chemical | 26380 | AZ 32 ≥98% | 2288709-96-4 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 26380 | AZ 32 ≥98% | 2288709-96-4 | 5mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 26380 | AZ 32 ≥98% | 2288709-96-4 | 10mg | $283 | 2024-03-01 | Buy |
AZ32 Chemical Properties,Uses,Production
Biological Activity
AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM.
in vitro
AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.
in vivo
AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours.
AZ32 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ32 Suppliers
Global( 37)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2990 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9756 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-
N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide
AZ32
Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR
2288709-96-4