|
|
| Product Name: | AZ32 | | Synonyms: | Benzamide, N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-;N-Methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)benzamide;AZ32;Ataxia telangiectasia mutated,ATM and RAD3 related,inhibit,Inhibitor,AZ 32,AZ-32,AZ32,ATM/ATR | | CAS: | 2288709-96-4 | | MF: | C20H16N4O | | MW: | 328.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2288709-96-4.mol |  |
| density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 150 mg/ml | | form | A solid | | pka | 14.63±0.46(Predicted) |
| Biological Activity | AZ32 is an oral, blood-brain barrier-penetrating ATM inhibitor with IC50<6.2 nM. Inhibits ATM in cells with IC50 of 0.31 μM. | | in vitro | AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro. | | in vivo | AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC 50 for approximately 22 hours. |
| | AZ32 Preparation Products And Raw materials |
|