ISOTHIPENDYL
- CAS No.
- 482-15-5
- Chemical Name:
- ISOTHIPENDYL
- Synonyms
- Adanton;Odantol;Udantol;Vdantor;Andantol;Andanton;AY 56012;Nilergex;Theruhistin;ISOTHIPENDYL
- CBNumber:
- CB3106204
- Molecular Formula:
- C16H19N3S
- Molecular Weight:
- 285.41
- MDL Number:
- MFCD00865664
- MOL File:
- 482-15-5.mol
| Boiling point | bp0.4mm 171-174° |
|---|---|
| Density | 1.1618 (rough estimate) |
| refractive index | 1.5605 (estimate) |
| pka | 8.82±0.50(Predicted) |
| FDA UNII | WVZ7K9P0JY |
| ATC code | D04AA22,R06AD09 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 in mice (mg/kg): 65 ±2 i.p.; 222 ±18 orally (Schlichtegroll) |
ISOTHIPENDYL price
ISOTHIPENDYL Chemical Properties,Uses,Production
Originator
Theruhistin,Ayerst,US,1957
Uses
Antihistaminic.
Definition
ChEBI: Isothipendyl is a tertiary amino compound and an aromatic amine.
Manufacturing Process
85 parts of phenylpyridyl amine, 21 parts of powdered sulfur and 1.7 parts of
iodine were heated to 275°C for two hours. Evolution of hydrogen sulfide
began when the mixture reached a temperature of 250°C and became
vigorous when it reached 275°C. Such evolution of hydrogen sulfide
diminished after about one hour at 275°C. A light oil was distilled from the
reaction mixture under vacuum (pressure = 2-3 mm Hg). This oil which
contained phenylpyridyl amine in addition to the thiophenylpyridyl amine was
then treated at boiling temperature with approximately the theoretical amount
of 2-3 normal HCl until complete solution resulted with formation of the HCl
salts of the amines. The solution was then treated with 1 to 2% (based upon
the substance mixture) of active carbon and then filtered hot. The nitrate was
then cooled to 0°C whereupon the thiophenylpyridyl amine hydrochloride
crystallized out while the phenylpyridyl amine hydrochloride remained in
solution. The thiophenylpyridyl amine hydrochloride was filtered off and
suspended in water and the pH adjusted with half concentrated ammonia to 8.
The thiophenylpyridyl amine set free was filtered off and dried. It was in the
form of gold yellow needles and had a melting point of 114°C to 115°C.
40 parts of thiophenylpyridyl amine were dissolved in 200 parts of water free
toluene. After the addition of 16 parts of soda amide, the mixture was
refluxed for 1% hours. Thereafter, 28 parts of dimethylaminoisopropyl chloride
in 30 parts of water free toluene were dropped in and the temperature
maintained at 20°C to 25°C for 30 minutes. Thereafter, the mixture was
heated at 60°C for 30 minutes and subsequently refluxed for 20 minutes.
Water and hydrochloride acid were then added to the reaction mixture and
this mixture rendered alkaline with NaOH and then the alkalized mixture
shaken out with ether. The dimethylaminoisopropyl-N9-thiophenylpyridyl
amine base thus obtained was vacuum distilled. It was then converted to
hydrochloride salt. The monohydrochloride salt is almost white in color and
melts at 213°C to 216°C. The yield was almost 100% of the theoretical.
Therapeutic Function
Antihistaminic
Safety Profile
A poison by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of NOx and SOx.
ISOTHIPENDYL Preparation Products And Raw materials
Raw materials
Preparation Products
ISOTHIPENDYL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9664 | 58 |
View Lastest Price from ISOTHIPENDYL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-18 | Isothipendyl USP/EP/BP | US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Isothipendyl USP/EP/BP
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited