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Siccanin

Siccanin structure

CAS No.: 22733-60-4

Chemical Name:: Siccanin

Synonyms: Siccanin;Sicanina;Siccanine;NSC 135048;Siccaninum;CS 280, SI 23548;Siccanin USP/EP/BP;Sicanina [inn-spanish];Siccanine [inn-french];1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol

CBNumber:: CB31120733

Molecular Formula:: C22H30O3

Molecular Weight:: 342.47

MDL Number:: MFCD32269323

MOL File:: 22733-60-4.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

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Siccanin Properties

Melting point	139-140°
alpha	D20 -136° (c = 2 in chloroform)
Boiling point	427.8±45.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form	A solid
pka	10.9(at 25℃)
FDA UNII	L702S858Z6

SAFETY

Risk and Safety Statements

Toxicity	LD50 in mice, rats (mg/kg): >6000, >1000 orally; >3000, >600 s.c. or i.p. (Suzuki)

Siccanin price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23654	Siccanin >98%	22733-60-4	1mg	$310	2024-03-01	Buy
Cayman Chemical	23654	Siccanin ≥98%	22733-60-4	5 mg	$1082	2024-03-01	Buy
Cayman Chemical	23654	Siccanin >98%	22733-60-4	500μg	$168	2022-04-27	Buy
TRC	S497055	Siccanin	22733-60-4	1mg	$230	2021-12-16	Buy
TRC	S497055	Siccanin	22733-60-4	2.5mg	$460	2021-12-16	Buy

Product number	Packaging	Price	Buy
23654	1mg	$310	Buy
23654	5 mg	$1082	Buy
23654	500μg	$168	Buy
S497055	1mg	$230	Buy
S497055	2.5mg	$460	Buy

Siccanin Chemical Properties,Uses,Production

Description

Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC₅₀s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of T. mentagrophytes (IC₅₀ = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of C. albicans strains with IC₅₀ values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.

Uses

Siccanin is an antifungal and SDHB (IP) inhibitor.

Uses

Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

Definition

ChEBI: Siccanin is an organic heteropentacyclic compound. It has a role as an antifungal drug and a fungal metabolite.

Origin

Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.

Biological Activity

Siccanin shows specific and strong ac tivity against the dermatophytes Trichophyton, Epidermophyton, and Microsporum, but ithas almost no activity against other fungi.

Siccanin Preparation Products And Raw materials

Raw materials

Preparation Products

Siccanin Suppliers

Global( 24)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3320	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	18521735133 18521732826;	market@aladdin-e.com	China	25015	65
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
BOC Sciences	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
ChemStrong Scientific Co.,Ltd	56
Lynnchem	58
Novachemistry	58

View Lastest Price from Siccanin manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	Siccanin USP/EP/BP 22733-60-4	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
	2020-05-13	Siccanin 22733-60-4	US $0.01-1.00 / KG	1KG	99%	50 tons	Shaanxi Dideu Medichem Co. Ltd

Siccanin USP/EP/BP
22733-60-4
US $1.10 / g
99.9%
Dideu Industries Group Limited

Siccanin
22733-60-4
US $0.01-1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

22733-60-4(Siccanin)Related Search:

Cyclohexyl(phenyl)methanol 4-CHROMANOL CHEMBRDG-BB 9070892 (S)-(-)-1-PHENYL-1-DECANOL Siccanin

Siccanin 1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl- (8CI) 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)- (9CI) 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, [4aS-(4aa,6aa,11ba,13aR*,13ba)]- NSC 135048 (13As)-1,2,3,4,4abeta,5,6,6A,11bbeta,13bbeta-decahydro-4,4,6abeta,9-tetramethyl-13H-benzo(A)furo(2,3,4-mn)xanthen-11-ol 13H-Benzo(A)furo(2,3,4-mn)xanthen-11-ol, 1,2,3,4,4A,5,6,6A,11B,13B-decahydro-4,4,6A,9-tetramethyl-, (4as-(4aalpha,6aalpha,11balpha,13ar*,13balpha))- Sicanina Sicanina [inn-spanish] Siccanine Siccanine [inn-french] Siccaninum CS 280, SI 23548 1H,11bH,13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 2,3,4,4a,5,6,6a,13b-octahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)- Siccanin USP/EP/BP 22733-60-4