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4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide structure

CAS No.: 284462-37-9

Chemical Name:: 4-(4-Aminophenoxy)-N-methylpicolinamide

Synonyms: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]

CBNumber:: CB31175425

Molecular Formula:: C13H13N3O2

Molecular Weight:: 243.26

MDL Number:: MFCD08692047

MOL File:: 284462-37-9.mol

Last updated:2024-04-01 10:27:31

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4-(4-Aminophenoxy)-N-methylpicolinamide Properties

Melting point	110-112°C
Boiling point	476.8±40.0 °C(Predicted)
Density	1.241±0.06 g/cm3(Predicted)
vapor pressure	0.001-0.05Pa at 20-109.84℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.96±0.46(Predicted)
color	White to Light yellow to Light orange
LogP	0.9 at 25℃ and pH7
Surface tension	71.71mN/m at 883.8mg/L and 20.1℃
FDA UNII	RE332HKD3U

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
HazardClass	IRRITANT
HS Code	2933399990

4-(4-Aminophenoxy)-N-methylpicolinamide price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2617	4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide >98.0%(HPLC)(T)	284462-37-9	1g	$30	2024-03-01	Buy
TCI Chemical	A2617	4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide >98.0%(HPLC)(T)	284462-37-9	5g	$91	2024-03-01	Buy
TRC	A618940	[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide	284462-37-9	500mg	$120	2021-12-16	Buy
TRC	A618940	[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide	284462-37-9	1g	$165	2021-12-16	Buy
Matrix Scientific	058611	4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide 95+%	284462-37-9	100g	$148	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2617	1g	$30	Buy
A2617	5g	$91	Buy
A618940	500mg	$120	Buy
A618940	1g	$165	Buy
058611	100g	$148	Buy

4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties,Uses,Production

Chemical Properties

Light-Brown Solid

Uses

Sorafenib intermediate

Synthesis

To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.

4-(4-Aminophenoxy)-N-methylpicolinamide synthesis

Synthesis of 4-(4-Aminophenoxy)-N-methylpicolinamide from Sorafenib Impurity 35

4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-4-(4-(3-(trifluoroMethyl)benzaMido)phenoxy)picolinaMide Tosylate Sorafenib

4-(4-Aminophenoxy)-N-methylpicolinamide Suppliers

Global( 420)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Henan Alfa Chemical Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 4-(4-Aminophenoxy)-N-methylpicolinamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-27	4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9	US $5.00-0.10 / KG	1KG	98%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-12-26	4-(4-aminophenoxy)-N-methyl-picolinamide 284462-37-9	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2023-07-25	4-(4-Aminophenoxy)-N-methylpicolinamide 284462-37-9	US $20.00-10.00 / kg	25kg	99%	200ton	Hebei Yanxi Chemical Co., Ltd.

4-(4-Aminophenoxy)-N-methylpicolinamide
284462-37-9
US $5.00-0.10 / KG
98%
Henan Fengda Chemical Co., Ltd

4-(4-aminophenoxy)-N-methyl-picolinamide
284462-37-9
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

4-(4-Aminophenoxy)-N-methylpicolinamide
284462-37-9
US $20.00-10.00 / kg
99%
Hebei Yanxi Chemical Co., Ltd.

284462-37-9(4-(4-Aminophenoxy)-N-methylpicolinamide)Related Search:

Sorafenib Sorafenib Impurity 35 Sorafenib Impurity 43 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Trimebutine maleate

PYRIDINE-2-CARBOXAMIDE N,N-Dimethylformamide N-Methylformamide SORAFENIB N-OXIDE Sorafenib tosylate

N-Methyl-4-chloropyridine-2-carboxamide 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine Sorafenib related compound 10 4-HYDROXYPHENYLFORMAMIDE

Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib Related Compound 21

1of4

4-(4-aMiNApheNAxy)-N-MethylpicolinaMide 4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide Sorafenib INT2 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate 4-(4-Aminophenoxy)-N-methylpicolinamide 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline [4-(4-Aminophenoxy-2-pyridyl)] 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide 4-(4-Aminophenoxy)-N-methylpicolimide [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide Sorafenib impurity A Sorafenib Intermediate Sorafenib Related Compound 23 Sorafen Sorafenib Aminophenoxy Impurity Sorafenib tosylate INT III N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide Sorafenib Intermediates II 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide > 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl- 4-(2-N-METHYLCARBOMOYL)-4-PYRIDYLOXY)ANILINE 4-(4-Aminophenoxy)-N-methylpicolinamide ISO 9001：2015 REACH 4-(4-Aminophenoxy)-N-methylpicolinamide (Sorafenib Impurity) 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide SL-M2 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide (IP2014) 284462-37-9 C13H13N3O2C2H2O4 Sorafinib Aromatics Compounds Aromatics Bases & Related Reagents Heterocycles Nucleotides Sorafenib tosylate 284462-37-9