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ChemicalBook >> CAS DataBase List >>3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE Structure
3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE structure
CAS No.
180637-89-2
Chemical Name:
3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE
Synonyms
Eletriptan Impurity 23;(R)5-(2-Benzenesulfonyl-vinyl)-3-(1-methyl-pyrrolidin-2-ylmethyl)-1H-indole;(R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole;(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole;3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE;(R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole;3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole;1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]-
CBNumber:
CB31476489
Molecular Formula:
C22H24N2O2S
Molecular Weight:
380.5
MDL Number:
MFCD09751002
MOL File:
180637-89-2.mol
MSDS File:
SDS
Last updated:2023-05-15 10:43:33
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3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE Properties

Boiling point 617.7±55.0 °C(Predicted)
Density 1.263
solubility soluble in Dichloromethane, Dimethylformamide, Methanol
pka 16.92±0.30(Predicted)
FDA UNII FEU571D9TF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS08,GHS07
Signal word  Danger
Hazard statements  H302-H317-H318-H373
Precautionary statements  P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P305+P351+P338-P310-P260-P314-P501

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FB18184 R-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole 180637-89-2 2mg $110 2021-12-16 Buy
Biosynth Carbosynth FB18184 R-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole 180637-89-2 5mg $199.9 2021-12-16 Buy
Biosynth Carbosynth FB18184 R-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole 180637-89-2 10mg $363.5 2021-12-16 Buy
American Custom Chemicals Corporation APN0000866 (R)-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-5-[2-(PHENYLSULFONYL)ETHENYL]-1H-INDOLE 95.00% 180637-89-2 5MG $496.4 2021-12-16 Buy
Medical Isotopes, Inc. 63079 R-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole 180637-89-2 5mg $610 2021-12-16 Buy
Product number Packaging Price Buy
FB18184 2mg $110 Buy
FB18184 5mg $199.9 Buy
FB18184 10mg $363.5 Buy
APN0000866 5MG $496.4 Buy
63079 5mg $610 Buy

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE Chemical Properties,Uses,Production

Chemical Properties

Red Solid

Uses

(R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is the free base of (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole Hydrobromide (B120725), which is an impurity of Eletriptan (E505000). Eletriptan is a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines (1,2,3). (R)-5-(2-Benzenesulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole is also an intermediate in the synthesis of 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-1-[1-[3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indol-5-yl]-2-(phenylsulfonyl)ethyl]-5-[(1E)-2-(phenylsulfonyl)ethenyl]-1H-indole (M320195).

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

Eletriptan Eletriptan hydrobromide

3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17367 58
Mainchem Co., Ltd. 		-- sarah@mainchem.com China 6572 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4901 55
Nanjing crow LuNing pharmaceutical technology co., LTD 13382066392 CHINA 4880 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55827 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 17825480238 3008233717@qq.com China 9844 12
Jinan blalong chemical co. LTD 2710913286@.com 1513643261@qq.com China 14253 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
Mainchem Co., Ltd. 		58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
AN PharmaTech Co Ltd 55
Nanjing crow LuNing pharmaceutical technology co., LTD 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 12
Jinan blalong chemical co. LTD 58
3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole 3-[((2R)-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-[(E)-2-(PHENYLSULFONYL)VINYL]INDOLE (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole (R)-3-((1-Methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)vinyl)-1H-indole (R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole Eletriptan Impurity 23 1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethenyl]- (R)5-(2-Benzenesulfonyl-vinyl)-3-(1-methyl-pyrrolidin-2-ylmethyl)-1H-indole 180637-89-2 Chiral Reagents Indole Derivatives Intermediates & Fine Chemicals Pharmaceuticals