R788(Fostamatinib disodium)
- CAS No.
- 1025687-58-4
- Chemical Name:
- R788(Fostamatinib disodium)
- Synonyms
- FosD;R 788 sodium;R788 disodium;R 935788 sodium;prodrug of R-406;Tamatinib Fosdium;Fo(R788) disodium;R788, Fostamatinib;R788 (sodium salt);FostaMatinib sodiuM
- CBNumber:
- CB32518272
- Molecular Formula:
- C23H27FN6NaO9P
- Molecular Weight:
- 604.46
- MDL Number:
- MFCD15146370
- MOL File:
- 1025687-58-4.mol
- MSDS File:
- SDS
| Melting point | >191°C (dec.) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White |
| Stability | Hygroscopic |
| NCI Dictionary of Cancer Terms | R788 sodium |
| FDA UNII | X9417132K8 |
R788(Fostamatinib disodium) price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18501 | R788 (sodium salt) ≥95% | 1025687-58-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18501 | R788 (sodium salt) ≥95% | 1025687-58-4 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18501 | R788 (sodium salt) ≥95% | 1025687-58-4 | 10mg | $341 | 2024-03-01 | Buy |
| Adipogen Life Sciences | SYN-1122-M010 | R788disodiumsalt ≥95% | 1025687-58-4 | 10mg | $324 | 2021-12-16 | Buy |
| ChemScene | CS-0427 | FostamatinibDisodium 99.88% | 1025687-58-4 | 5mg | $96 | 2021-12-16 | Buy |
R788(Fostamatinib disodium) Chemical Properties,Uses,Production
Uses
R 788 Sodium Salt is the sodium salt of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.
Biological Activity
r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).
in vitro
r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].
in vivo
r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].
target
Syk
References
[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7.
[2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.
[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.
R788(Fostamatinib disodium) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29118 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from R788(Fostamatinib disodium) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | Fostamatinib disodium
1025687-58-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-08-07 | R788(Fostamatinib disodium)
1025687-58-4
|
US $3.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Fostamatinib disodium
1025687-58-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- R788(Fostamatinib disodium)
1025687-58-4
- US $3.00 / KG
- 99%
- Career Henan Chemical Co