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CAL-101

CAS No.
870281-82-6
Chemical Name:
CAL-101
Synonyms
Idelalisib(CAL-101);-101;CS-34;GS1101;AL-101;CAL-11;CAL-101;CAL-101 1KG;CAL101,CAL-101;CAL-101, >=98%
CBNumber:
CB32538915
Molecular Formula:
C22H18FN7O
Molecular Weight:
415.42
MDL Number:
MFCD19443647
MOL File:
870281-82-6.mol
Last updated:2023-10-09 22:51:44

CAL-101 Properties

Melting point 250-252oC
Boiling point 733.4±70.0 °C(Predicted)
Density 1.47
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form White solid.
pka 10.00±0.10(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
FDA UNII YG57I8T5M0

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H372
Precautionary statements  P260-P264-P270-P314-P501
Safety Statements  V
HS Code  29399990

CAL-101 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15279 CAL-101 ≥98% 870281-82-6 5mg $33 2024-03-01 Buy
Cayman Chemical 15279 CAL-101 ≥98% 870281-82-6 10mg $63 2024-03-01 Buy
Cayman Chemical 15279 CAL-101 ≥98% 870281-82-6 25mg $107 2024-03-01 Buy
Cayman Chemical 15279 CAL-101 ≥98% 870281-82-6 50mg $164 2024-03-01 Buy
TRC C124800 CAL-101 870281-82-6 100mg $285 2021-12-16 Buy
Product number Packaging Price Buy
15279 5mg $33 Buy
15279 10mg $63 Buy
15279 25mg $107 Buy
15279 50mg $164 Buy
C124800 100mg $285 Buy

CAL-101 Chemical Properties,Uses,Production

Description

Idelalisib (CAS 870281-82-6) is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5

Uses

CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.

Definition

ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.

target

p110δ

storage

Store at -20°C

References

1) Herman?et al. (2010), Phosphatidylinositol 2-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals; Blood?116 2078 2) Lannutti?et al. (2011), CAL-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability; Blood 117 591 3) Ahmad?et al. (2017), Differential PI3Kd Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy; Cancer Res. 77 1892 4) Lim?et al. (2018), Phosphoinositide 3-kinase d inhibition promotes antitumor responses but antagonizes checkpoint inhibitors; JCI Insight 3 e120626 5) Palazzo?et al.?(2018),?The PI3Kd-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augment B Cell Depletion In Vivo; J.Immunol. 200 2304

870281-86-0
87-42-3
870281-82-6
Synthesis of CAL-101 from (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one and 6-Chloropurine

CAL-101 Preparation Products And Raw materials

Global( 284)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Rokechem Technology Co., Ltd.
18758118018 sales001@rokechem.com China 255 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Lianyungang happen teng technology co., LTD
15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338 stella@zetchem.com China 2141 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hangzhou Cyanochem Co., Ltd.
+86 17788583750 sales@cyanochem.com CHINA 283 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58

View Lastest Price from CAL-101 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CAL-101 pictures 2023-10-09 CAL-101
870281-82-6
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
Idelalisib pictures 2022-10-01 Idelalisib
870281-82-6
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Idelalisib(CAL-101) pictures 2022-08-12 Idelalisib(CAL-101)
870281-82-6
US $0.00-0.00 / kg 1kg 99%min 1-50kg Changzhou Rokechem Technology Co., Ltd.
  • CAL-101 pictures
  • CAL-101
    870281-82-6
  • US $0.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • Idelalisib pictures
  • Idelalisib
    870281-82-6
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
CAL101,CAL-101 CAL-101 GS1101 CAL-101 (GS-1101) 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101 (Idelalisib, GS-1101) (S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylaMino)propyl]- 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-one 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101 (Idelalisib, GS-1101) CAL-101 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101(IDELALISIB) AL-101 CAL-101(IDELALISIB) AL-101 CAL-101, >=98% Idelalisib, CAL-101, GS-1101 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101 1KG CAL-11 IDELALISIB; CAL-101; GS-1101; GS 1101; GS1101;CAL101 CS-34 Idelalisib (This product is only available in Japan.) CAL-101, 99%, a selective p110δ inhibitor 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]- -101 CAL-101 USP/EP/BP Idelalisib (CAL101, Zydelig, GS1101) 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-qui... Idelalisib(CAL-101) Idelalisib,PI3K,CAL101,CAL 101,GS 1101,Phosphoinositide 3-kinase,Autophagy,Inhibitor,inhibit,GS1101 (S)-2-(1-((9H-Purin-6-yl)ami)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 870281-82-6 10870281-82-6 C22H18FN7O Akt mTOR PI3K Inhibitors Inhibitor API API