Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>R-(-)-Apomorphine

R-(-)-Apomorphine

R-(-)-Apomorphine Structure
R-(-)-Apomorphine structure
CAS No.
41372-20-7
Chemical Name:
R-(-)-Apomorphine
Synonyms
Apokyn;R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE;r-(-)-apomorphine;Apokyn HeMihydrate;Ixense HeMihydrate;ApoMorphin HeMihydrate;ApoMorphine HeMihydrate;Apomorphine HCl hydrate;APOMORPHINEHCLHEMIHYDRATE;Apomophine hydrochloride
CBNumber:
CB3447114
Molecular Formula:
C17H20ClNO3
Molecular Weight:
321.8
MDL Number:
MFCD27966809
MOL File:
41372-20-7.mol
Last updated:2023-06-29 17:13:30
Request For Quotation

R-(-)-Apomorphine Properties

Melting point 285-287 °C(lit.)
alpha -48 º (c=1, H2O)
storage temp. Refrigerator
solubility H2O: ~10 mg/mL, clear, yellow-green
color white to gray
PH pH(10g/l, 25℃) : 4.0～5.0
Merck 13,751
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
CAS DataBase Reference 41372-20-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F39049Y068

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P330+P331+P310
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933997000

R-(-)-Apomorphine price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2621 Apomorphine hydrochloride PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial 41372-20-7 500MG $226 2024-03-01 Buy
Sigma-Aldrich A4393 R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5% 41372-20-7 1g $290 2024-03-01 Buy
Sigma-Aldrich 1041008 Apomorphine hydrochloride United States Pharmacopeia (USP) Reference Standard 41372-20-7 250mg $457 2024-03-01 Buy
Sigma-Aldrich A4393 R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5% 41372-20-7 100mg $57.7 2024-03-01 Buy
Sigma-Aldrich A4393 R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5% 41372-20-7 250mg $95.3 2024-03-01 Buy
Product number Packaging Price Buy
PHR2621 500MG $226 Buy
A4393 1g $290 Buy
1041008 250mg $457 Buy
A4393 100mg $57.7 Buy
A4393 250mg $95.3 Buy

R-(-)-Apomorphine Chemical Properties,Uses,Production

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical Properties

Off-White Solid

Uses

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

Uses

Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.

Uses

emetic, antiparkinsonian, erextile dysfunction therapy

brand name

Apokyn (Vernalis).

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

R-(-)-Apomorphine Preparation Products And Raw materials

Raw materials

MORPHINE Sodium sulfite CHLOROETHANE Activated carbon,decolor

Preparation Products

R-(-)-Apomorphine Suppliers

Global( 87)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3581 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9320 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Hebei Dangtong Import and export Co LTD 		+8615632927689 admin@hbdangtong.com China 991 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49999 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
Henan Bao Enluo International TradeCo.，LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Hebei Dangtong Import and export Co LTD 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58

View Lastest Price from R-(-)-Apomorphine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
R-(-)-Apomorphine pictures 2024-04-26 R-(-)-Apomorphine
41372-20-7
 US $11500.00-11460.00 / kilograms 10kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
R-(-)-Apomorphine pictures 2023-06-30 R-(-)-Apomorphine
41372-20-7
 US $10.00 / kg 1kg 99.99% 50000tons Henan Bao Enluo International TradeCo.，LTD
R-(-)-Apomorphine USP/EP/BP pictures 2021-08-04 R-(-)-Apomorphine USP/EP/BP
41372-20-7
 US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited
  • R-(-)-Apomorphine pictures
  • R-(-)-Apomorphine
    41372-20-7
  • US $11500.00-11460.00 / kilograms
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • R-(-)-Apomorphine pictures
  • R-(-)-Apomorphine
    41372-20-7
  • US $10.00 / kg
  • 99.99%
  • Henan Bao Enluo International TradeCo.，LTD

R-(-)-Apomorphine Spectrum

R-(-)-Apomorphine(41372-20-7)1HNMRR-(-)-Apomorphine(41372-20-7)RamanR-(-)-Apomorphine(41372-20-7)IR

41372-20-7(R-(-)-Apomorphine)Related Search:

Quinhydrone Ethoxyquin Methyl acetate 8-Hydroxyquinoline Kresoxim-methyl
Thiophanate-methyl Methyl acrylate Bensulfuron methyl Quinoline Yellow 2-METHYL-1,3-PROPANEDIOL
Isoquinoline Poly(tetrahydrofuran) Methylparaben Quinclorac Methyl
Parathion-methyl MORPHINE apomorphine

1of4

(r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol Apomorphine hydrochloride R-(-)- (6Ar)-5,6,6A,7-tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid 6a-beta-aporphine-10,11-diol APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE 4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)- APOMORPHINEHCLHEMIHYDRATE APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP Apomophine hydrochloride R-(-)-Apomorphine hemihydrate hydrochloride 4H-Dibenzo(de,G)quinoline-10,11-diol, 5,6,6A,7-tetrahydro-6-methyl-, hydrochloride, hemihydrate, (R)- Apomorphin hydrochlorid wasser (2/1) Apomorphine Hydrochloride (250 mg) (-)-10,11-Dihydroxy-aporphine Hydrochloride HeMihydrate (6aR)-5,6,6a,7-Tetrahydro-6-Methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride HeMihydrate 6aβ-Aporphine-10,11-diol Hydrochloride HeMihydrate Apokyn HeMihydrate ApoMorphin HeMihydrate ApoMorphine HeMihydrate Ixense HeMihydrate l-ApoMorphine HeMihydrate r-(-)-apomorphine:6a-beta-aporphine-10,11-diol: (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)QUINOLINE-10,11-diol R-(-)-Apomorphine HCl Hemihydrate r-(-)-apomorphine Apomorphine hydrochloride hemihydrate CRS Apomorphine HCl hydrate R-(-)-Apomorphine USP/EP/BP Apomorphine Hydrochloride (1041008) Apokyn R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE a . N-(2-a mi noe th yl)-2-(b e nzylph e nyla mi no)a c e ta mi d e . Apomorphine HCl Reference Standard 41372-20-7 C17H18ClNO212H2O C17H17NO2HCl12H2O C17H17NO222HClH2O C17H20ClNO3 C17H18ClNO2H2O 31279 Nonselective dopamine agonist; causes nausea and emesis. Chiral Building Blocks Asymmetric Synthesis Others Heterocyclic Building Blocks Inhibitors APOKYN Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Agonists Dopaminergics Neurotransmitters Erectile Dysfunction Dopamine receptor